M
Maria A. O'Connell
Researcher at University of East Anglia
Publications - 83
Citations - 3837
Maria A. O'Connell is an academic researcher from University of East Anglia. The author has contributed to research in topics: Tumor necrosis factor alpha & Protein kinase C. The author has an hindex of 33, co-authored 82 publications receiving 3491 citations. Previous affiliations of Maria A. O'Connell include Trinity College, Dublin & MRC Human Nutrition Research.
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Journal ArticleDOI
Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.
Mausumee Guha,Maria A. O'Connell,Maria A. O'Connell,Maria A. O'Connell,Rafal Pawlinski,Rafal Pawlinski,Rafal Pawlinski,Angela Hollis,Angela Hollis,Angela Hollis,Patricia McGovern,Patricia McGovern,Patricia McGovern,Shi Fang Yan,Shi Fang Yan,Shi Fang Yan,David M. Stern,David M. Stern,David M. Stern,Nigel Mackman,Nigel Mackman,Nigel Mackman +21 more
TL;DR: The data indicate that LPS induction of Egr-1 gene expression is required for maximal induction of the TNF-alpha and TF genes in human monocytic cells.
Journal ArticleDOI
Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts.
Celia J. Prynne,Gita D. Mishra,Maria A. O'Connell,Graciela Muniz,M. Ann Laskey,Liya Yan,Ann Prentice,Fiona Ginty +7 more
TL;DR: Higher fruit and vegetable intakes may have positive effects on bone mineral status in both younger and older age groups, especially at the spine and femoral neck.
Journal ArticleDOI
Role of IKK1 and IKK2 in Lipopolysaccharide Signaling in Human Monocytic Cells
TL;DR: The results indicate that LPS induction of κB-dependent gene expression in human monocytic cells requires activation of IKK2, which is consistent with previous reports on tumor necrosis factor and interleukin 1 signaling pathways.
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Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes
TL;DR: It is shown for the first time that LPS induces NQO1 and HO-1 expression in human monocytes via Nrf2 to modulate their inflammatory responsiveness, thus providing novel potential therapeutic strategies for the treatment of sepsis.
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Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C
TL;DR: Results indicate that LPS-induced HO-1 expression in human monocytic cells requires Nrf2 and PKC.