M
María Ángeles López-García
Researcher at Spanish National Research Council
Publications - 30
Citations - 2625
María Ángeles López-García is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 21, co-authored 28 publications receiving 2394 citations. Previous affiliations of María Ángeles López-García include Services Hospital & The Breast Cancer Research Foundation.
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Journal ArticleDOI
FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer
Nicholas C. Turner,Alex Pearson,Rachel Sharpe,Maryou B K Lambros,Felipe C. Geyer,María Ángeles López-García,Rachael Natrajan,Caterina Marchiò,Elizabeth Iorns,Alan Mackay,Cheryl Gillett,Anita Grigoriadis,Andrew Tutt,Jorge S. Reis-Filho,Alan Ashworth +14 more
TL;DR: The data suggest that amplification and overexpression of FGFR1 may be a major contributor to poor prognosis in luminal-type breast cancers, driving anchorage-independent proliferation and endocrine therapy resistance.
Journal ArticleDOI
Breast cancer precursors revisited: molecular features and progression pathways.
María Ángeles López-García,Felipe C. Geyer,Magali Lacroix-Triki,Caterina Marchiò,Jorge S. Reis-Filho +4 more
TL;DR: Breast cancer precursors revisited: molecular features and progression pathways revisited.
Journal ArticleDOI
The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type.
Britta Weigelt,Felipe C. Geyer,Rachael Natrajan,María Ángeles López-García,María Ángeles López-García,Amar Ahmad,Kay Savage,Bas Kreike,Jorge S. Reis-Filho +8 more
TL;DR: It is demonstrated that classic ILCs differ from grade‐ and molecular subtype‐matched IDCs in the expression of genes related to cell adhesion, cell‐to‐cell signalling, and actin cytoskeleton signalling and should be considered as part of a spectrum of lesions.
Journal ArticleDOI
Micro-RNA signature of the epithelial–mesenchymal transition in endometrial carcinosarcoma
María Ángeles Castilla,Gema Moreno-Bueno,Laura Romero-Pérez,Koen Van de Vijver,Michele Biscuola,María Ángeles López-García,Jaime Prat,Xavier Matias-Guiu,Amparo Cano,Esther Oliva,José Palacios +10 more
TL;DR: Analysis of microRNA signatures associated to EMT in human carcinosarcomas suggests that the interplay between transcriptional repressors of E‐cadherin and miRNAs provides a link between EMT‐activation and the maintenance of stemness.
Journal ArticleDOI
Adenoid cystic carcinomas constitute a genomically distinct subgroup of triple-negative and basal-like breast cancers†
Daniel Wetterskog,María Ángeles López-García,María Ángeles López-García,Maryou B. Lambros,Roger A'Hern,Felipe C. Geyer,Fernanda Milanezi,Maria C Cabral,Rachael Natrajan,Arnaud Gauthier,Kai-Keen Shiu,Nick Orr,Sami Shousha,Zoran Gatalica,Alan Mackay,J Palacios,Jorge S. Reis-Filho,Britta Weigelt +17 more
TL;DR: Breast AdCCs constitute an entity distinct from grade‐matched and triple‐ negative and basal‐like IDC‐NSTs, emphasizing the importance of histological subtyping of triple‐negative and basal-like breast carcinomas.