M
Maria Buur Nordskov Gabe
Researcher at University of Copenhagen
Publications - 22
Citations - 1156
Maria Buur Nordskov Gabe is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Receptor & Glucagon. The author has an hindex of 13, co-authored 18 publications receiving 729 citations.
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Journal ArticleDOI
The impact of short chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon
C. Christiansen,Maria Buur Nordskov Gabe,Berit Svendsen,Lars O. Dragsted,Mette M. Rosenkilde,Jens J. Holst +5 more
TL;DR: It is shown that short-chain fatty acids (SCFAs) primarily are used as a colonocyte energy source in the rat, subsequently triggering glucagon like peptide-1 (GLP-1) secretion independent of the free fatty acid receptors FFAR2 and FFAR3.
Journal ArticleDOI
Insulin Secretion Depends on Intra-islet Glucagon Signaling
Berit Svendsen,Olav Larsen,Maria Buur Nordskov Gabe,C. Christiansen,Mette M. Rosenkilde,Daniel J. Drucker,Jens J. Holst +6 more
TL;DR: The results suggest that combined activity of glucagon and GLP-1 receptors is essential for β cell secretory responses, emphasizing a role for paracrine intra-islet glucagon actions to maintain appropriate insulin secretion.
Journal ArticleDOI
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
Francis S. Willard,Jonathan D. Douros,Maria Buur Nordskov Gabe,Aaron D. Showalter,David B. Wainscott,Todd M. Suter,Megan E. Capozzi,Wijnand J.C. van der Velden,Cynthia Stutsman,Guemalli R. Cardona,Shweta Urva,Paul J. Emmerson,Jens J. Holst,David A. D'Alessio,Matthew P. Coghlan,Mette M. Rosenkilde,Jonathan E. Campbell,Kyle W. Sloop +17 more
TL;DR: This analysis reveals a greater degree of engagement of tirzepatide for the GIP receptor than the GLP-1 receptor, corroborating an imbalanced mechanism of action.
Journal ArticleDOI
Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals.
Lærke S. Gasbjerg,Lærke S. Gasbjerg,Mads M. Helsted,Bolette Hartmann,Mette H. Jensen,Maria Buur Nordskov Gabe,Alexander Hovard Sparre-Ulrich,Simon Veedfald,Signe Stensen,Signe Stensen,Amalie R. Lanng,Amalie R. Lanng,Natasha C. Bergmann,Natasha C. Bergmann,Mikkel B. Christensen,Mikkel B. Christensen,Tina Vilsbøll,Tina Vilsbøll,Jens J. Holst,Mette M. Rosenkilde,Filip K. Knop,Filip K. Knop +21 more
TL;DR: Examining the individual and combined contributions of endogenous GIP and GLP-1 to the postprandial changes in glucose and glucoregulatory hormones using the novel GIP receptor antagonist GIP(3-30)NH2 and the well-established GLp-1 receptor antagonist exendin(9-39) NH2 found that A and C resulted in higher glucagon levels and faster gastric emptying.
Journal ArticleDOI
GIP(3 - 30)NH 2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study
Lærke S. Gasbjerg,Mikkel B. Christensen,Bolette Hartmann,Amalie R. Lanng,Alexander Hovard Sparre-Ulrich,Maria Buur Nordskov Gabe,Flemming Dela,Tina Vilsbøll,Jens J. Holst,Mette M. Rosenkilde,Filip K. Knop +10 more
TL;DR: GIP(3-30)NH2 was evaluated with homologous receptor binding and receptor activation (cAMP accumulation) studies at the glucagon-like peptide 1 (GLP-1), GLP-2, glucagon, secretin and growth hormone-releasing hormone (GHRH) receptors as discussed by the authors.