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Alexander Hovard Sparre-Ulrich
Researcher at University of Copenhagen
Publications - 30
Citations - 1607
Alexander Hovard Sparre-Ulrich is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Receptor & Chemokine receptor. The author has an hindex of 16, co-authored 25 publications receiving 1271 citations.
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Journal ArticleDOI
International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
Françoise Bachelerie,Adit Ben-Baruch,Amanda M. Burkhardt,Christophe Combadière,Joshua M. Farber,Gerard J. Graham,Richard Horuk,Alexander Hovard Sparre-Ulrich,Massimo Locati,Andrew D. Luster,Alberto Mantovani,Kouji Matsushima,Philip M. Murphy,Robert J. B. Nibbs,Hisayuki Nomiyama,Christine Power,Amanda E. I. Proudfoot,Mette M. Rosenkilde,Antal Rot,Silvano Sozzani,Marcus Thelen,Osamu Yoshie,Albert Zlotnik +22 more
TL;DR: This work reviews this extended family of chemokine receptors and Chemokine-binding proteins at the basic, translational, and clinical levels, including an update on drug development and introduces a new nomenclature for atypical chemokin receptors with the stem ACKR (atypicalChemokine receptor).
Journal ArticleDOI
Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals.
Lærke S. Gasbjerg,Lærke S. Gasbjerg,Mads M. Helsted,Bolette Hartmann,Mette H. Jensen,Maria Buur Nordskov Gabe,Alexander Hovard Sparre-Ulrich,Simon Veedfald,Signe Stensen,Signe Stensen,Amalie R. Lanng,Amalie R. Lanng,Natasha C. Bergmann,Natasha C. Bergmann,Mikkel B. Christensen,Mikkel B. Christensen,Tina Vilsbøll,Tina Vilsbøll,Jens J. Holst,Mette M. Rosenkilde,Filip K. Knop,Filip K. Knop +21 more
TL;DR: Examining the individual and combined contributions of endogenous GIP and GLP-1 to the postprandial changes in glucose and glucoregulatory hormones using the novel GIP receptor antagonist GIP(3-30)NH2 and the well-established GLp-1 receptor antagonist exendin(9-39) NH2 found that A and C resulted in higher glucagon levels and faster gastric emptying.
Journal ArticleDOI
The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor
Meena Asmar,Ali Asmar,Lene Simonsen,Lærke S. Gasbjerg,Alexander Hovard Sparre-Ulrich,Mette M. Rosenkilde,Bolette Hartmann,Flemming Dela,Jens J. Holst,Jens Bülow +9 more
TL;DR: The changes in glucose infusion rates and plasma insulin levels demonstrate an inhibitory effect of the antagonist on the incretin effect of GIP, indicating that GIP also plays a crucial role in lipid metabolism.
Journal ArticleDOI
N‐terminally and C‐terminally truncated forms of glucose‐dependent insulinotropic polypeptide are high‐affinity competitive antagonists of the human GIP receptor
L S Hansen,Alexander Hovard Sparre-Ulrich,Mikkel Christensen,Filip K. Knop,B. Hartmann,J. J. Holst,Mette M. Rosenkilde +6 more
TL;DR: Eight N‐terminal truncations of human GIP(1–30)NH2 are characterized and high‐affinity ligands for the GIP receptor are needed to elucidate the physiological functions and pharmacological potential of GIP in vivo.
Journal ArticleDOI
Species-specific action of (Pro3)GIP – a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors
Alexander Hovard Sparre-Ulrich,L S Hansen,Berit Svendsen,Mikkel Christensen,Filip K. Knop,B. Hartmann,J. J. Holst,Mette M. Rosenkilde +7 more
TL;DR: In this paper, a pharmacological analysis of (Pro3)GIP including interspecies differences between the rodent and human GIP system was conducted, and it was shown that Rodent GIPs are more potent and efficacious at their receptors than humanGIPs.