M
Maria Castella
Researcher at Fred Hutchinson Cancer Research Center
Publications - 32
Citations - 1971
Maria Castella is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Chimeric antigen receptor & Fanconi anemia. The author has an hindex of 18, co-authored 27 publications receiving 1669 citations. Previous affiliations of Maria Castella include Carlos III Health Institute & University of British Columbia.
Papers
More filters
Journal ArticleDOI
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells
Angel Raya,Ignasi Rodríguez-Pizà,Guillermo Guenechea,Rita Vassena,Susana Navarro,Maria J. Barrero,Antonella Consiglio,Maria Castella,Paula Río,Eduard Sleep,Federico Gonzalez,Gustavo Tiscornia,Elena Garreta,Trond Aasen,Anna Veiga,Inder M. Verma,Jordi Surrallés,Juan A. Bueren,Juan Carlos Izpisua Belmonte +18 more
TL;DR: It is shown that corrected Fanconi-anaemia-specific iPS cells can give rise to haematopoietic progenitors of the myeloid and erythroid lineages that are phenotypically normal, that is, disease-free.
Journal ArticleDOI
Ataxia-Pancytopenia Syndrome Is Caused by Missense Mutations in SAMD9L.
Dong Hui Chen,Jennifer E. Below,Akiko Shimamura,Sioban Keel,Mark Matsushita,John Wolff,Youngmee Sul,Emily Bonkowski,Maria Castella,Toshiyasu Taniguchi,Deborah A. Nickerson,Thalia Papayannopoulou,Thomas D. Bird,Thomas D. Bird,Wendy H. Raskind,Wendy H. Raskind +15 more
TL;DR: The hematopoietic cytopenias that characterize AP syndrome and the selective advantage for clones that have lost the mutant allele support the postulated role of SAMD9L in the regulation of cell proliferation.
Journal ArticleDOI
Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability
Massimo Bogliolo,Alex Lyakhovich,Elsa Callen,Maria Castella,Enrico Cappelli,María José Ramírez,Amadeu Creus,Ricard Marcos,Reinhard Kalb,Kornelia Neveling,Detlev Schindler,Jordi Surrallés,Jordi Surrallés +12 more
TL;DR: Induced subnuclear accumulation of DNA damage is induced to prove that histone H2AX is a novel component of the FA/BRCA pathway in response to stalled replication forks and is functionally connected to theFA/BrcA pathway to resolve stalled replication Fork and prevent chromosome instability.
Journal ArticleDOI
Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations
Maria Castella,Maria Castella,Roser Pujol,Roser Pujol,Elsa Callen,Elsa Callen,Juan P. Trujillo,José A. Casado,Hans J. J. P. Gille,Francis P. Lach,Arleen D. Auerbach,Detlev Schindler,Javier Benitez,Beatriz Porto,Teresa Ferro,Muñoz A,Julián Sevilla,Luis Madero,Elena Cela,Cristina Beléndez,Cristina Díaz de Heredia,T Olivé,José Sánchez de Toledo,Isabel Badell,Montserrat Torrent,Jesús Estella,Angeles Dasí,Antonia Rodríguez-Villa,Pedro Gómez,José Barbot,María Tapia,Antonio Molinés,A. Figuera,Juan A. Bueren,Jordi Surrallés,Jordi Surrallés +35 more
TL;DR: It is proved that long distance Alu-Alu recombination can cause Fanconi anemia by originating large interstitial deletions involving FANCA and 2 adjacent genes, and it is shown that all missense mutations studied lead to an altered FAN CA protein that is unable to relocate to the nucleus and activate the FA/BRCA pathway.
Journal ArticleDOI
Clinical and Molecular Characteristics of Squamous Cell Carcinomas From Fanconi Anemia Patients
Hester J.T. van Zeeburg,Peter J.F. Snijders,Thijs Wu,Eliane Gluckman,Jean Soulier,Jordi Surrallés,Maria Castella,Jacqueline E. van der Wal,Johan Wennerberg,Joseph A. Califano,Eunike Velleuer,Ralf Dietrich,Wolfram Ebell,Elisabeth Bloemena,Hans Joenje,C. René Leemans,Ruud H. Brakenhoff +16 more
TL;DR: The data show that HPV does not play a major role in squamous cell carcinogenesis in this cohort of Fanconi anemia patients and that the FanconiAnemia SCCs are genetically similar to sporadic S CCs despite having a different etiology.