Maria de Lourdes G. Ferreira

TL;DR: Derivatives of isoniazid (INH), (E)-N'-[(1-aryl)-1H-1,2,3-triazole-4-yl)methylene] isonicotinoyl hydrazides, exhibited significant activity and displayed low cytotoxicity against liver cells and kidney cells, thereby providing a high therapeutic index.

TL;DR: The design, synthesis, and antiviral activity of new nucleoside ribavirin analogs are described based on the following: ring bioisosterism of a 1,2,4-triazole for a 1%, and amide group exchange for other substituents, such as c-propyl, methyl carboxylate, or trifluoromethyl groups.

TL;DR: This work synthesized 11 new quinoline‐1H‐1,2,3‐triazole hybrids with different substituents in the 4‐positions of the 1H‐2‐chloroquine‐resistant P. falciparum clone, exhibiting good selectivity indexes, as high 351 for one compound.

TL;DR: In this paper, a three-component one-pot synthesis of 2-isopropyl-3-benzyl-1,3-thiazolidin-4-ones and 2-phenyl- 3-isobutyl- 1,3 -thiazolines from valine, arenealdehydes and mercaptoacetic acid with good yields is reported.

TL;DR: The 1H-pyrazolo[3,4-b]pyridine system appears to be promising for further studies as an antimalarial for overcoming the burden of resistance in P. falciparum.