Maria Despoina Charavgi

TL;DR: In this paper, the same azide and substituted acetylenes gave 1-(β-d -glucopyranosyl)-4-substituted-1,2,3-triazoles in Cu(I)-catalyzed azide-alkyne cycloadditions.

TL;DR: 5-Phenyltetrazole was transformed into 5-ethynyl- as well as 5-chloromethyl-2-(O-perbenzoylated-β-D-glucopyranosyl)-1,3,4-oxadiazoles by acylation with propiolic acid-DCC or chloroacetyl chloride by the Zemplén protocol.

TL;DR: These are the first crystal structures of a thermophilic GE both in an unliganded form and bound to a substrate analogue, thus unravelling the organization of the catalytic triad residues and their neighbours lining the active site.

TL;DR: A group of 15 aromatic aldehyde 4-(β-d-glucopyranosyl)thiosemicarbazones have been synthesized and evaluated as inhibitors of rabbit muscle glycogen phosphorylase b by kinetic studies, revealing that the inhibitors are accommodated at the catalytic site with the glucopyranusyl moiety at approximately the same position as α- d-glue and stabilize the T conformation of the 280s loop.

TL;DR: The three-level experimental procedure not merely facilitates routine, fast and simple biochemical characterizations but it can also give rise to the discovery of different GEs through an extensive screening of heterologous Genomic and Metagenomic expression libraries.