Maria Grazia Palmerini

TL;DR: The subcellular structure of human mature oocytes following vitrification is discussed at the light of most relevant ultrastructural studies, which may actually provide a great insight in this debate on oocyte integrity.

TL;DR: The data suggest that oocytes with low developmental competence have a slowed down energetic metabolism which delays later development and mitochondria and their functional aggregation during maturation play an active role to provide energy in terms of ATP.

TL;DR: These findings support the idea that ovarian cancer cells can modulate fibroblast behaviour through the release of EVs, activating them to a CAFs-like state; the latter are able, in turn, to stimulate the surrounding cells.

TL;DR: Reduced maturation rates of immature oocytes vitrified prior to IVM can be, at least in part, explained by underlying ultrastructural and biomolecular alterations.

TL;DR: It is shown that the GV stage appears more suitable for vitrification than the MII stage, as indicated by the good ultrastructural preservation of important structures that are present only in immature oocytes, like the nucleus and migrating CGs.