M
Maria Hadjifrangiskou
Researcher at Vanderbilt University Medical Center
Publications - 59
Citations - 2734
Maria Hadjifrangiskou is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Escherichia coli & Medicine. The author has an hindex of 24, co-authored 44 publications receiving 2073 citations. Previous affiliations of Maria Hadjifrangiskou include University of Texas Health Science Center at Houston & Monroe Carell Jr. Children's Hospital at Vanderbilt.
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Journal ArticleDOI
Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era
TL;DR: A general review of the steps leading to biofilm formation on surfaces and within eukaryotic cells is provided, highlighting several medically important pathogens, and recent advances on novel strategies aimed at biofilm prevention and/or dissolution are discussed.
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Escherichia coli Biofilms Have an Organized and Complex Extracellular Matrix Structure
Chia S. Hung,Yizhou Zhou,Jerome S. Pinkner,Karen W. Dodson,Jan R. Crowley,John E. Heuser,Matthew George Chapman,Maria Hadjifrangiskou,Jeffrey P. Henderson,Scott J. Hultgren +9 more
TL;DR: It is shown that uropathogenic Escherichia coli (UPEC) strains produce a biofilm with a highly ordered and complex extracellular matrix (ECM) that protects biofilm bacteria from environmental insults and also makes the dissolution of biofilms very challenging.
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Options and Limitations in Clinical Investigation of Bacterial Biofilms
Maria Magana,Christina Sereti,Anastasios Ioannidis,Courtney A. Mitchell,Anthony R. Ball,Emmanouil Magiorkinis,Stylianos Chatzipanagiotou,Michael R. Hamblin,Michael R. Hamblin,Maria Hadjifrangiskou,George P. Tegos +10 more
TL;DR: A synopsis of the methodological landscape of biofilm analysis is provided, including an evaluation of the current trends in methodological research, and recommendations defining the most appropriate methodological tools for clinical settings are made.
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QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli.
TL;DR: It is discovered that QseC has phosphatase activity required for QseB dephosphorylation, which is critical for modulatingQseB activity and subsequent gene expression, and that this is not a UPEC‐specific phenomenon.
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Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection
Kanna Nagamatsu,Thomas J. Hannan,Randi L. Guest,Maria Kostakioti,Maria Hadjifrangiskou,Jana Binkley,Karen W. Dodson,Tracy L. Raivio,Scott J. Hultgren +8 more
TL;DR: Investigating host–pathogen dynamics in human urothelial cells in vitro and in murine model of acute cystitis discovered that fine-tuning of HlyA expression by the CpxRA system is critical for enhancing UPEC fitness in the urinary bladder.