M
Maria Karayiorgou
Researcher at Columbia University
Publications - 81
Citations - 9553
Maria Karayiorgou is an academic researcher from Columbia University. The author has contributed to research in topics: Catechol-O-methyl transferase & Schizophrenia. The author has an hindex of 43, co-authored 80 publications receiving 8895 citations. Previous affiliations of Maria Karayiorgou include University of Pretoria & Columbia University Medical Center.
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Journal ArticleDOI
Chronic Adolescent Exposure to Δ-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Psychosis-Related and Other Phenotypes
Colm M. P. O’Tuathaigh,Magdalena Hryniewiecka,Áine T. Behan,Orna Tighe,Catherine A. Coughlan,Lieve Desbonnet,Mary Cannon,Maria Karayiorgou,Joseph A. Gogos,David Cotter,John L. Waddington +10 more
TL;DR: The COMT genotype exerts specific modulation of responsivity to chronic THC administration during adolescence in terms of exploratory activity, spatial working memory, and anxiety, which illuminate the interaction between genes and adverse environmental exposures over a particular stage of development in the expression of the psychosis phenotype.
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Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase.
Daniela Babovic,Colm M. P. O’Tuathaigh,A.M. O'Connor,Gerard J. O'Sullivan,Orna Tighe,David T. Croke,Maria Karayiorgou,Joseph A. Gogos,David Cotter,John L. Waddington +9 more
TL;DR: The data suggest that catechol-O-methyltransferase and neuregulin-1 may influence, respectively, primarily cognitive and social endophenotypes of the overall schizophrenia syndrome.
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MicroRNA dysregulation in neuropsychiatric disorders and cognitive dysfunction
TL;DR: Possible mechanisms that underlie the contribution of individual miRNAs and miRNA-related pathways to the pathogenesis and pathophysiology of these complex clinical phenotypes are explored.
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Decreased phosphorylation of NMDA receptor type 1 at serine 897 in brains of patients with Schizophrenia.
TL;DR: It is shown that in two independent samples of brains from patients with schizophrenia, a significant decrease in the phosphorylation level at serine 897 (S897) of the NMDA receptor type 1 (NR1) subunit is shown, suggesting that insufficientosphorylation at S897 may contribute to the neuronal pathology underlying schizophrenia.
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Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism
Iuliana Ionita-Laza,Bin Xu,Vlad Makarov,Joseph D. Buxbaum,J. Louw Roos,Joseph A. Gogos,Maria Karayiorgou +6 more
TL;DR: Variants in one gene, Fanconi-associated nuclease 1 (FAN1), are identified as being associated with both SCZ and ASD, and the finding suggests that FAN1 is a key driver in the 15q13.3 locus for the associated psychiatric and neurodevelopmental phenotypes.