J
John L. Waddington
Researcher at Royal College of Surgeons in Ireland
Publications - 437
Citations - 29950
John L. Waddington is an academic researcher from Royal College of Surgeons in Ireland. The author has contributed to research in topics: Schizophrenia & Dopamine receptor. The author has an hindex of 71, co-authored 424 publications receiving 26238 citations. Previous affiliations of John L. Waddington include Stanley Foundation & Cavan General Hospital.
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Journal ArticleDOI
Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai-How Farh,Peter Holmans,Phil Lee,Phil Lee,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,David A. Collier,David A. Collier,Hailiang Huang,Hailiang Huang,Tune H. Pers,Tune H. Pers,Tune H. Pers,Ingrid Agartz,Ingrid Agartz,Esben Agerbo,Esben Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Ronald Y.L. Chen,Eric Y.H. Chen,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Ditte Demontis,Ditte Demontis,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Gary Donohoe,Elodie Drapeau,Jubao Duan,Frank Dudbridge,Naser Durmishi,Peter Eichhammer,Johan G. Eriksson,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Marion Friedl,Joseph I. Friedman,Menachem Fromer,Menachem Fromer,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Ina Giegling,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jacqueline I. Goldstein,Jacqueline I. Goldstein,Vera Golimbet,Srihari Gopal,Jacob Gratten,Lieuwe de Haan,Christian Hammer,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Stefan Herms,Joel N. Hirschhorn,Joel N. Hirschhorn,Per Hoffmann,Per Hoffmann,A. Hofman,Mads V. Hollegaard,David M. Hougaard,Masashi Ikeda,Inge Joa,Antonio Julià,René S. Kahn,Luba Kalaydjieva,Sena Karachanak-Yankova,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,James L. Kennedy,Andrey Khrunin,Yunjung Kim,Janis Klovins,James A. Knowles,Bettina Konte,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Hana Kuzelova-Ptackova,Anna K. Kähler,Claudine Laurent,Jimmy Lee Chee Keong,S. Hong Lee,Sophie E. Legge,Bernard Lerer,Miaoxin Li,Tao Li,Kung-Yee Liang,Jeffrey A. Lieberman,Svetlana A. Limborska,Carmel M. Loughland,Jan Lubinski,Jouko Lönnqvist,Milan Macek,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,J. Mallet,Sara Marsal,Manuel Mattheisen,Manuel Mattheisen,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Derek W. Morris,Ole Mors,Ole Mors,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Bertram Mueller-Myhsok,Mari Nelis,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Liene Nikitina-Zake,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,F. Anthony O'Neill,Sang-Yun Oh,Ann Olincy,Line Olsen,Jim van Os,Jim van Os,Christos Pantelis,George N. Papadimitriou,Sergi Papiol,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Tiina Paunio,Milica Pejovic-Milovancevic,Diana O. Perkins,Olli Pietiläinen,Olli Pietiläinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes L. Price,Alkes L. Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Ulrich Schall,Christian R. Schubert,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Engilbert Sigurdsson,Teimuraz Silagadze,Jeremy M. Silverman,Jeremy M. Silverman,Kang Sim,Petr Slominsky,Jordan W. Smoller,Jordan W. Smoller,Hon-Cheong So,Chris C. A. Spencer,Eli A. Stahl,Eli A. Stahl,Hreinn Stefansson,Stacy Steinberg,Elisabeth Stögmann,Richard E. Straub,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Mythily Subramaniam,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Erik Söderman,Srinivas Thirumalai,Draga Toncheva,Sarah Tosato,Juha Veijola,John L. Waddington,Dermot Walsh,Dai Wang,Qiang Wang,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Emily H. M. Wong,Brandon Wormley,Hualin Simon Xi,Clement C. Zai,Xuebin Zheng,Fritz Zimprich,Naomi R. Wray,Kari Stefansson,Peter M. Visscher,Rolf Adolfsson,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Anders D. Børglum,Anders D. Børglum,Sven Cichon,Sven Cichon,Ariel Darvasi,Enrico Domenici,Hannelore Ehrenreich,Tõnu Esko,Tõnu Esko,Tõnu Esko,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
TL;DR: Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Journal ArticleDOI
Rare chromosomal deletions and duplications increase risk of schizophrenia
Jennifer Stone,Jennifer Stone,Jennifer Stone,Michael Conlon O'Donovan,Hugh Gurling,George Kirov,Douglas Blackwood,Aiden Corvin,Nicholas John Craddock,Michael Gill,Christina M. Hultman,Christina M. Hultman,Paul Lichtenstein,Andrew McQuillin,Carlos N. Pato,Douglas M. Ruderfer,Douglas M. Ruderfer,Douglas M. Ruderfer,Michael John Owen,David St Clair,Patrick F. Sullivan,Pamela Sklar,Pamela Sklar,Pamela Sklar,Shaun Purcell,Shaun Purcell,Shaun Purcell,Joshua M. Korn,Joshua M. Korn,Stuart MacGregor,Derek W. Morris,Colm O'Dushlaine,Mark J. Daly,Mark J. Daly,Mark J. Daly,Peter M. Visscher,Peter Holmans,Edward M. Scolnick,Edward M. Scolnick,Nigel Williams,Lucy Georgieva,Ivan Nikolov,Nadine Norton,Hywel Williams,Draga Toncheva,Vihra Milanova,Emma Flordal Thelander,Patrick Sullivan,Elaine Kenny,John L. Waddington,Khalid Choudhury,Susmita Datta,Jonathan Pimm,Srinivasa Thirumalai,Vinay Puri,Robert Krasucki,Jacob Lawrence,Digby Quested,Nicholas Bass,David Curtis,Caroline Crombie,Gillian Fraser,Soh Leh Kwan,Nicholas Walker,Walter J. Muir,Kevin A. McGhee,Ben S. Pickard,P. Malloy,Alan W Maclean,Margaret Van Beck,Michele T. Pato,Helena Medeiros,Frank A. Middleton,Célia Barreto Carvalho,Christopher P. Morley,Ayman H. Fanous,David V. Conti,James A. Knowles,Carlos Ferreira,António Macedo,M. Helena Azevedo,Steve McCarroll,Steve McCarroll,Mark J. Daly,Mark J. Daly,Mark J. Daly,Kimberly Chambert,Kimberly Chambert,Casey Gates,Stacey Gabriel,Scott Mahon,Kristen Ardlie +91 more
TL;DR: A genome-wide survey of rare CNVs in 3,391 patients with schizophrenia and 3,181 ancestrally matched controls provides strong support for a model of schizophrenia pathogenesis that includes the effects of multiple rare structural variants, both genome- wide and at specific loci.
Journal ArticleDOI
Analysis of shared heritability in common disorders of the brain
Verneri Anttila,Verneri Anttila,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,Hilary K. Finucane,Raymond K. Walters,Raymond K. Walters,Jose Bras,Laramie E. Duncan,Valentina Escott-Price,Guido J. Falcone,Padhraig Gormley,Rainer Malik,Nikolaos A. Patsopoulos,Nikolaos A. Patsopoulos,Stephan Ripke,Zhi Wei,Dongmei Yu,Dongmei Yu,Phil Lee,Phil Lee,Patrick Turley,Patrick Turley,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Vincent Chouraki,Yoichiro Kamatani,Claudine Berr,Claudine Berr,Luc Letenneur,Luc Letenneur,Didier Hannequin,Philippe Amouyel,Anne Boland,Jean-François Deleuze,Emmanuelle Duron,Badri N. Vardarajan,Christiane Reitz,Alison Goate,Matthew J. Huentelman,M. Ilyas Kamboh,Eric B. Larson,Eric B. Larson,Ekaterina Rogaeva,Peter St George-Hyslop,Peter St George-Hyslop,Hakon Hakonarson,Walter A. Kukull,Lindsay A. Farrer,Lisa L. Barnes,Thomas G. Beach,F. Yesim Demirci,Elizabeth Head,Christine M. Hulette,Gregory A. Jicha,John S. K. Kauwe,Jeffrey Kaye,James B. Leverenz,Allan I. Levey,Andrew P. Lieberman,Vernon S. Pankratz,Wayne W. Poon,Joseph F. Quinn,Joseph F. Quinn,Andrew J. Saykin,Lon S. Schneider,Amanda Smith,Joshua A. Sonnen,Joshua A. Sonnen,Robert S. Stern,Vivianna M. Van Deerlin,Linda J. Van Eldik,Denise Harold,Giancarlo Russo,David C. Rubinsztein,Anthony Bayer,Magda Tsolaki,Petra Proitsi,Nick C. Fox,Nick C. Fox,Harald Hampel,Michael John Owen,Simon Mead,Peter Passmore,Kevin Morgan,Markus M. Noethen,Martin N. Rossor,Michelle K. Lupton,Michelle K. Lupton,Per Hoffmann,Johannes Kornhuber,Brian A. Lawlor,Andrew McQuillin,Ammar Al-Chalabi,Ammar Al-Chalabi,Joshua C. Bis,Agustín Ruiz,Mercè Boada,Sudha Seshadri,Sudha Seshadri,Alexa S. Beiser,Kenneth Rice,Sven J. van der Lee,Philip L. De Jager,Daniel H. Geschwind,Matthias Riemenschneider,Steffi G. Riedel-Heller,Jerome I. Rotter,Gerhard Ransmayr,Bradley T. Hyman,Carlos Cruchaga,Montserrat Alegret,Bendik S. Winsvold,Priit Palta,Priit Palta,K.-H. Farh,K.-H. Farh,E. Cuenca-Leon,E. Cuenca-Leon,Nicholas A. Furlotte,Tobias Kurth,Lannie Ligthart,Gisela M. Terwindt,Tobias Freilinger,Tobias Freilinger,Caroline Ran,Scott D. Gordon,Guntram Borck,Hieab H.H. Adams,Terho Lehtimäki,Juho Wedenoja,Julie E. Buring,Markus Schuerks,Maria Gudlaug Hrafnsdottir,Jouke-Jan Hottenga,Brenda W.J.H. Penninx,Ville Artto,Mari A. Kaunisto,Salli Vepsäläinen,Nicholas G. Martin,Grant W. Montgomery,Grant W. Montgomery,Mitja I. Kurki,Eija Hämäläinen,Hailiang Huang,Hailiang Huang,Jie Huang,Cynthia Sandor,Caleb Webber,Caleb Webber,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Stefan Schreiber,Veikko Salomaa,Elizabeth Loehrer,Hartmut Goebel,Alfons Macaya,Patricia Pozo-Rosich,Thomas Hansen,Thomas Werge,Thomas Werge,Jaakko Kaprio,Andres Metspalu,Christian Kubisch,Michel D. Ferrari,Andrea Carmine Belin,Arn M. J. M. van den Maagdenberg,John-Anker Zwart,Dorret I. Boomsma,Nicholas Eriksson,Jes Olesen,Daniel I. Chasman,Daniel I. Chasman,Dale R. Nyholt,Andreja Avbersek,Larry Baum,Samuel F. Berkovic,Jonathan P. Bradfield,Russell J. Buono,Russell J. Buono,Russell J. Buono,Claudia B. Catarino,Claudia B. Catarino,Patrick Cossette,Peter De Jonghe,Chantal Depondt,Dennis J. Dlugos,Dennis J. Dlugos,Thomas N. Ferraro,Thomas N. Ferraro,Jacqueline A. French,Helle Hjalgrim,Jennifer Jamnadas-Khoda,Jennifer Jamnadas-Khoda,Reetta Kälviäinen,Wolfram S. Kunz,Holger Lerche,Costin Leu,Dick Lindhout,Dick Lindhout,Warren D. Lo,Warren D. Lo,Daniel H. Lowenstein,Mark McCormack,Mark McCormack,Rikke S. Møller,Anne M. Molloy,Ping-Wing Ng,Karen Oliver,Michael Privitera,Rodney A. Radtke,Ann-Kathrin Ruppert,Thomas Sander,Steven C. Schachter,Steven C. Schachter,Christoph J. Schankin,Christoph J. Schankin,Ingrid E. Scheffer,Ingrid E. Scheffer,Susanne Schoch,Sanjay M. Sisodiya,Philip E. M. Smith,Michael R. Sperling,Pasquale Striano,Rainer Surges,Rainer Surges,G. Neil Thomas,Frank Visscher,Christopher D. Whelan,Federico Zara,Erin L. Heinzen,Anthony G Marson,Anthony G Marson,Felicitas Becker,H. Stroink,Fritz Zimprich,Thomas Gasser,Thomas Gasser,Raphael Gibbs,Peter Heutink,Peter Heutink,Maria Martinez,Maria Martinez,Huw R. Morris,Manu Sharma,Mina Ryten,Kin Y. Mok,Kin Y. Mok,Sara L. Pulit,Sara L. Pulit,Sara L. Pulit,Steve Bevan,Elizabeth G. Holliday,John Attia,Thomas W.K. Battey,Giorgio B. Boncoraglio,Vincent Thijs,Wei-Min Chen,Braxton D. Mitchell,Braxton D. Mitchell,Peter M. Rothwell,Pankaj Sharma,Pankaj Sharma,Cathie Sudlow,Astrid M. Vicente,Hugh S. Markus,Christina Kourkoulis,Christina Kourkoulis,Joana Pera,Miriam R. Raffeld,Scott Silliman,Vesna Boraska Perica,Laura M. Thornton,Laura M. Huckins,N. William Rayner,N. William Rayner,Cathryn M. Lewis,Mònica Gratacòs,Filip Rybakowski,Anna Keski-Rahkonen,Anu Raevuori,Anu Raevuori,James I. Hudson,Ted Reichborn-Kjennerud,Ted Reichborn-Kjennerud,Palmiero Monteleone,Andreas Karwautz,Katrin Männik,Katrin Männik,Jessica H. Baker,Julie K. O'Toole,Sara E. Trace,Oliver S. P. Davis,Sietske G. Helder,Stefan Ehrlich,Beate Herpertz-Dahlmann,Unna N. Danner,Annemarie A. van Elburg,Maurizio Clementi,Monica Forzan,Elisa Docampo,Jolanta Lissowska,Joanna Hauser,Alfonso Tortorella,Mario Maj,Fragiskos Gonidakis,Konstantinos Tziouvas,Hana Papezova,Zeynep Yilmaz,Gudrun Wagner,Sarah Cohen-Woods,Stefan Herms,Antonio Julià,Raquel Rabionet,Danielle M. Dick,Samuli Ripatti,Samuli Ripatti,Ole A. Andreassen,Ole A. Andreassen,Thomas Espeseth,Thomas Espeseth,Astri J. Lundervold,Vidar M. Steen,Vidar M. Steen,Dalila Pinto,Stephen W. Scherer,Stephen W. Scherer,Harald N. Aschauer,Alexandra Schosser,Lars Alfredsson,Leonid Padyukov,Katherine A. Halmi,James E. Mitchell,Michael Strober,Andrew W. Bergen,Walter H. Kaye,Jin P. Szatkiewicz,Bru Cormand,Josep Antoni Ramos-Quiroga,Cristina Sánchez-Mora,Cristina Sánchez-Mora,Marta Ribasés,Marta Ribasés,Miguel Casas,Amaia Hervás,Maria Arranz,Jan Haavik,Jan Haavik,Tetyana Zayats,Tetyana Zayats,Stefan Johansson,Stefan Johansson,Nigel Williams,Astrid Dempfle,Aribert Rothenberger,Jonna Kuntsi,Robert D. Oades,Tobias Banaschewski,Barbara Franke,Jan K. Buitelaar,Alejandro Arias Vasquez,Alysa E. Doyle,Andreas Reif,Klaus-Peter Lesch,Klaus-Peter Lesch,Klaus-Peter Lesch,Christine M. Freitag,Olga Rivero,Haukur Palmason,Marcel Romanos,Kate Langley,Marcella Rietschel,Stephanie H. Witt,Soeren Dalsgaard,Soeren Dalsgaard,Anders D. Børglum,Irwin D. Waldman,Beth Wilmot,Nikolas Molly,Claiton H.D. Bau,Jennifer Crosbie,Russell Schachar,Russell Schachar,Sandra K.,James J. McGough,Eugenio H. Grevet,Sarah E. Medland,Elise B. Robinson,Elise B. Robinson,Lauren A. Weiss,Elena Bacchelli,Anthony J. Bailey,Vanessa H. Bal,Agatino Battaglia,Catalina Betancur,Patrick Bolton,Rita M. Cantor,Patrícia B. S. Celestino-Soper,Geraldine Dawson,Silvia De Rubeis,Frederico Duque,Andrew Green,Andrew Green,Sabine M. Klauck,Marion Leboyer,Marion Leboyer,Pat Levitt,Pat Levitt,Elena Maestrini,Shrikant M. Mane,Daniel Moreno-De-Luca,Daniel Moreno-De-Luca,Jeremy R. Parr,Jeremy R. Parr,Jeremy R. Parr,Regina Regan,Abraham Reichenberg,Sven Sandin,Sven Sandin,Jacob A. S. Vorstman,Thomas H. Wassink,Ellen M. Wijsman,Edwin H. Cook,Susan L. Santangelo,Susan L. Santangelo,Richard Delorme,Richard Delorme,Bernadette Rogé,Bernadette Rogé,Tiago R. Magalhaes,Dan E. Arking,Thomas G. Schulze,Robert C. Thompson,Robert C. Thompson,Jana Strohmaier,Keith Matthews,Keith Matthews,Ingrid Melle,Ingrid Melle,Derek W. Morris,Douglas Blackwood,Andrew M. McIntosh,Sarah E. Bergen,Martin Schalling,Martin Schalling,Stéphane Jamain,Stéphane Jamain,Anna Maaser,Anna Maaser,Sascha B. Fischer,Sascha B. Fischer,Céline S. Reinbold,Céline S. Reinbold,Janice M. Fullerton,Janice M. Fullerton,Jose Guzman-Parra,Fermín Mayoral,Peter R. Schofield,Peter R. Schofield,Sven Cichon,Sven Cichon,Sven Cichon,Thomas W. Mühleisen,Thomas W. Mühleisen,Franziska Degenhardt,Johannes Schumacher,Michael Bauer,Philip B. Mitchell,Philip B. Mitchell,Elliot S. Gershon,John P. Rice,James B. Potash,Peter P. Zandi,Nicholas John Craddock,I. Nicol Ferrier,Martin Alda,Martin Alda,Guy A. Rouleau,Guy A. Rouleau,Gustavo Turecki,Roel A. Ophoff,Carlos N. Pato,Adebayo Anjorin,Eli A. Stahl,Eli A. Stahl,Markus Leber,Piotr M. Czerski,Cristiana Cruceanu,Ian Jones,Danielle Posthuma,Danielle Posthuma,Till F. M. Andlauer,Till F. M. Andlauer,Andreas J. Forstner,Fabian Streit,Bernhard T. Baune,Tracy Air,Grant Sinnamon,Grant Sinnamon,Naomi R. Wray,Donald J. MacIntyre,David J. Porteous,Georg Homuth,Margarita Rivera,Margarita Rivera,Jakob Grove,Christel M. Middeldorp,Christel M. Middeldorp,Christel M. Middeldorp,Ian B. Hickie,Michele L. Pergadia,Divya Mehta,Divya Mehta,Johannes H. Smit,Johannes H. Smit,Rick Jansen,Eco J. C. de Geus,Eco J. C. de Geus,Erin C. Dunn,Qingqin S. Li,Matthias Nauck,Robert A. Schoevers,Aartjan T.F. Beekman,James A. Knowles,Alexander Viktorin,Paul D. Arnold,Paul D. Arnold,Cathy L. Barr,Cathy L. Barr,Cathy L. Barr,Gabriel Bedoya-Berrio,O. Joseph Bienvenu,Helena Brentani,Christie L. Burton,Beatriz Camarena,Carolina Cappi,Danielle C. Cath,Maria Cristina Cavallini,Daniele Cusi,Sabrina M. Darrow,Damiaan Denys,Damiaan Denys,Eske M. Derks,Andrea Dietrich,Andrea Dietrich,Thomas V. Fernandez,Martijn Figee,Martijn Figee,Nelson B. Freimer,Gloria Gerber,Marco A. Grados,Erica Greenberg,Gregory L. Hanna,Andreas Hartmann,Matthew E. Hirschtritt,Pieter J. Hoekstra,Alden Y. Huang,Alden Y. Huang,Chaim Huyser,Cornelia Illmann,Michael A. Jenike,Samuel Kuperman,Bennett L. Leventhal,Christine Lochner,Gholson J. Lyon,Fabio Macciardi,Marcos Madruga-Garrido,Irene A. Malaty,Athanasios Maras,Lauren M. McGrath,Euripedes Constantino Miguel,Pablo Mir,Gerald Nestadt,Humberto Nicolini,Michael S. Okun,Andrew J. Pakstis,Peristera Paschou,John Piacentini,Christopher Pittenger,Kerstin J. Plessen,Kerstin J. Plessen,Vasily Ramensky,Eliana Marisa Ramos,Victor I. Reus,Margaret A. Richter,Margaret A. Richter,Mark A. Riddle,Mary M. Robertson,Veit Roessner,Maria Conceição do Rosário,Maria Conceição do Rosário,Jack Samuels,Paul Sandor,Paul Sandor,Dan J. Stein,Dan J. Stein,Fotis Tsetsos,Filip Van Nieuwerburgh,Sarah Weatherall,Jens R. Wendland,Tomasz Wolańczyk,Yulia Worbe,Gwyneth Zai,Fernando S. Goes,Nicole C.R. McLaughlin,Nicole C.R. McLaughlin,Paul S. Nestadt,Hans-Jörgen Grabe,Christel Depienne,Christel Depienne,Christel Depienne,Anuar Konkashbaev,Nuria Lanzagorta,Ana Victoria Valencia-Duarte,Ana Victoria Valencia-Duarte,Elvira Bramon,Nancy G. Buccola,Wiepke Cahn,Murray J. Cairns,Siow A. Chong,David Cohen,Benedicto Crespo-Facorro,Benedicto Crespo-Facorro,James J. Crowley,Michael Davidson,Lynn E. DeLisi,Lynn E. DeLisi,Timothy G. Dinan,Gary Donohoe,Elodie Drapeau,Jubao Duan,Jubao Duan,Lieuwe de Haan,David M. Hougaard,Sena Karachanak-Yankova,Andrey Khrunin,Janis Klovins,Vaidutis Kučinskas,Jimmy Lee Chee Keong,Svetlana A. Limborska,Carmel M. Loughland,Jouko Lönnqvist,Jouko Lönnqvist,Brion S. Maher,Manuel Mattheisen,Manuel Mattheisen,Colm McDonald,Kieran C. Murphy,Igor Nenadic,Jim van Os,Jim van Os,Jim van Os,Christos Pantelis,Christos Pantelis,Michele T. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Digby Quested,Digby Quested,Panos Roussos,Alan R. Sanders,Alan R. Sanders,Ulrich Schall,Sibylle G. Schwab,Kang Sim,Kang Sim,Hon-Cheong So,Hon-Cheong So,Elisabeth Stoegmann,Elisabeth Stoegmann,Mythily Subramaniam,Draga Toncheva,John L. Waddington,James T.R. Walters,Mark Weiser,Mark Weiser,Wei Cheng,Robert C. Cloninger,David Curtis,David Curtis,Pablo V. Gejman,Pablo V. Gejman,Frans Henskens,Morten Mattingsdal,Sang-Yun Oh,Sang-Yun Oh,Rodney J. Scott,Rodney J. Scott,Bradley T. Webb,Gerome Breen,Claire Churchhouse,Claire Churchhouse,Cynthia M. Bulik,Cynthia M. Bulik,Mark J. Daly,Mark J. Daly,Martin Dichgans,Stephen V. Faraone,Rita Guerreiro,Peter Holmans,Kenneth S. Kendler,Bobby P. C. Koeleman,Carol A. Mathews,Alkes L. Price,Alkes L. Price,Jeremiah M. Scharf,Pamela Sklar,Julie Williams,Nicholas W. Wood,Chris Cotsapas,Chris Cotsapas,Aarno Palotie,Jordan W. Smoller,Jordan W. Smoller,Patrick F. Sullivan,Jonathan Rosand,Aiden Corvin,Aiden Corvin,Benjamin M. Neale,Benjamin M. Neale +720 more
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
Journal ArticleDOI
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
Bjarni J. Vilhjálmsson,Jian Yang,Hilary K. Finucane,Alexander Gusev,Sara Lindström,Stephan Ripke,Giulio Genovese,Po-Ru Loh,Gaurav Bhatia,Ron Do,Tristan J. Hayeck,Hong-Hee Won,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai How Farh,Peter Holmans,Phil Lee,Brendan Bulik-Sullivan,David A. Collier,Hailiang Huang,Tune H. Pers,Ingrid Agartz,E. Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Ronald Y.L. Chen,Eric Y.H. Chen,Wei Cheng,Eric F. C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Lynn E. DeLisi,Ditte Demontis,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Elodie Drapeau,Jubao Duan,Frank Dudbridge,Naser Durmishi,Peter Eichhammer,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Marion Friedl,Joseph I. Friedman,Menachem Fromer,Lyudmila Georgieva,Elliot S. Gershon,Ina Giegling,Paola Giusti-Rodrguez,Stephanie Godard,Jacqueline I. Goldstein,Vera Golimbet,Srihari Gopal,Jacob Gratten,Jakob Grove,Lieuwe de Haan,Christian Hammer,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Joel N. Hirschhorn,Per Hoffmann,A. Hofman,Mads V. Hollegaard,David M. Hougaard,Masashi Ikeda,Inge Joa,Antonio Julià,René S. Kahn,Luba Kalaydjieva,Sena Karachanak-Yankova,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,Brian Kelly,James L. Kennedy,Andrey Khrunin,Yunjung Kim,Janis Klovins,James A. Knowles,Bettina Konte,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Hana Kuzelova-Ptackova,Anna K. Kähler,Claudine Laurent,Jimmy Lee Chee Keong,S. Hong Lee,Sophie E. Legge,Bernard Lerer,Miaoxin Li,Tao Li,Kung Yee Liang,Jeffrey A. Lieberman,Svetlana A. Limborska,Carmel M. Loughland,Jan Lubinski,Jouko K. Lnnqvist,Milan Macek,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,Jacques Mallet,Sara Marsal,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Ole Mors,Preben Bo Mortensen,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Bertram Mller-Myhsok,Mari Nelis,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Liene Nikitina-Zake,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,F. Anthony O'Neill,Sang Yun Oh,Ann Olincy,Line Olsen,Jim van Os,Christos Pantelis,George N. Papadimitriou,Sergi Papiol,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Milica Pejovic-Milovancevic,Diana O. Perkins,Olli Pietilinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Ulrich Schall,Christian Schubert,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Engilbert Sigurdsson,Teimuraz Silagadze,Jeremy M. Silverman,Kang Sim,Petr Slominsky,Jordan W. Smoller,Hon-Cheong So,Chris C. A. Spencer,Eli A. Stahl,Hreinn Stefansson,Stacy Steinberg,Elisabeth Stögmann,Richard E. Straub,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Mythily Subramaniam,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Erik Sderman,Srinivas Thirumalai,Draga Toncheva,Paul A. Tooney,Sarah Tosato,Juha Veijola,John L. Waddington,Dermot Walsh,Dai Wang,Qiang Wang,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Emily H. M. Wong,Brandon Wormley,Jing Qin Wu,Hualin Simon Xi,Clement C. Zai,Xuebin Zheng,Fritz Zimprich,Naomi R. Wray,Kari Stefansson,Peter M. Visscher,Rolf Adolfsson,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Anders D. Børglum,Sven Cichon,Ariel Darvasi,Enrico Domenici,Hannelore Ehrenreich,Tõnu Esko,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Anil K. Malhotra,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Bryan J. Mowry,Markus M. Nthen,Roel A. Ophoff,Michael John Owen,A. Palotie,Carlos N. Pato,Tracey L. Petryshen,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Mark J. Daly,Patrick F. Sullivan,Michael Conlon O'Donovan,Peter Kraft,David J. Hunter,Muriel A. Adank,Habibul Ahsan,Kristiina Aittomäki,Laura Baglietto,Sonja I. Berndt,Carl Blomquist,Federico Canzian,Jenny Chang-Claude,Stephen J. Chanock,Laura Crisponi,Kamila Czene,Norbert Dahmen,Isabel dos Santos Silva,Douglas F. Easton,A. Heather Eliassen,Jonine D. Figueroa,Olivia Fletcher,Montserrat Garcia-Closas,Mia M. Gaudet,Lorna Gibson,Christopher A. Haiman,Per Hall,Aditi Hazra,Rebecca Hein,Brian E. Henderson,Albert Hofman,John L. Hopper,Astrid Irwanto,Mattias Johansson,Rudolf Kaaks,Muhammad G. Kibriya,Peter Lichtner,Eiliv Lund,Enes Makalic,Alfons Meindl,Hanne Meijers-Heijboer,Bertram Müller-Myhsok,Taru A. Muranen,Heli Nevanlinna,Petra H.M. Peeters,Julian Peto,Ross L. Prentice,Nazneen Rahman,María José Sánchez,Daniel F. Schmidt,Rita K. Schmutzler,Melissa C. Southey,Rulla M. Tamimi,Ruth C. Travis,Clare Turnbull,André G. Uitterlinden,Rob B. van der Luijt,Quinten Waisfisz,Zhaoming Wang,Alice S. Whittemore,Rose Yang,Wei Zheng,Wei Zheng,Sekar Kathiresan,Michele T. Pato,Carlos N. Pato,E Stahl,Noah Zaitlen,Bogdan Pasaniuc,Gillian M. Belbin,Eimear E. Kenny,Mikkel H. Schierup,Phillip L. De Jager,Nikolaos A. Patsopoulos,Steve McCarroll,Mark J. Daly,Shaun M. Purcell,Daniel I. Chasman,Benjamin M. Neale,Michael E. Goddard,Nick Patterson,Alkes L. Price +394 more
TL;DR: LDpred is introduced, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel, and outperforms the approach of pruning followed by thresholding, particularly at large sample sizes.
Journal ArticleDOI
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Christian R. Marshall,Daniel P. Howrigan,Daniel P. Howrigan,Daniele Merico,Bhooma Thiruvahindrapuram,Wenting Wu,Douglas S. Greer,Danny Antaki,Aniket Shetty,Peter Holmans,Peter Holmans,Dalila Pinto,Madhusudan Gujral,William M. Brandler,Dheeraj Malhotra,Dheeraj Malhotra,Zhouzhi Wang,Karin V Fuentes Fajarado,Michelle S. Maile,Stephan Ripke,Stephan Ripke,Ingrid Agartz,Ingrid Agartz,Margot Albus,Madeline Alexander,Farooq Amin,Farooq Amin,Joshua R. Atkins,Silviu Alin Bacanu,Rich Belliveau,Sarah E. Bergen,Sarah E. Bergen,Marcelo Bertalan,Marcelo Bertalan,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,William Byerley,Wiepke Cahn,Guiqing Cai,Murray J. Cairns,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberley D. Chambert,Wei Cheng,C. Robert Cloninger,David Cohen,Paul Cormican,Nicholas John Craddock,Nicholas John Craddock,Benedicto Crespo-Facorro,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Lynn E. DeLisi,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Srdjan Djurovic,Gary Donohoe,Gary Donohoe,Elodie Drapeau,Jubao Duan,Jubao Duan,Frank Dudbridge,Peter Eichhammer,Joel Eriksson,Joel Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Kai How Farh,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Joseph I. Friedman,Andreas J. Forstner,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Elliot S. Gershon,Ina Giegling,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jackie Goldstein,Jackie Goldstein,Jacob Gratten,Lieuwe de Haan,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Thomas Hansen,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Stefan Herms,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Per Hoffmann,Per Hoffmann,A. Hofman,Hailiang Huang,Hailiang Huang,Masashi Ikeda,Inge Joa,Anna K. Kähler,René S. Kahn,Luba Kalaydjieva,Juha Karjalainen,David H. Kavanagh,Matthew C. Keller,Brian Kelly,James L. Kennedy,James L. Kennedy,Yunjung Kim,James A. Knowles,Bettina Konte,Claudine Laurent,Pui Y. Lee,Pui Y. Lee,Sang Hong Lee,Sophie E. Legge,Bernard Lerer,Deborah L. Levy,Deborah L. Levy,Kung Yee Liang,Jeffrey A. Lieberman,Jouko Lönnqvist,Carmel M. Loughland,Patrik K. E. Magnusson,Brady J. Maher,Wolfgang Maier,Jacques Mallet,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Ingrid Melle,Ingrid Melle,Raquelle I. Mesholam-Gately,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Derek W. Morris,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,Sang-Yun Oh,Ann Olincy,Line Olsen,Line Olsen,Francis A. O'Neill,Jim van Os,Jim van Os,Christos Pantelis,George N. Papadimitriou,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Diana O. Perkins,Tune H. Pers,Tune H. Pers,Tune H. Pers,Olli Pietiläinen,Olli Pietiläinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes L. Price,Alkes L. Price,Ann E. Pulver,Shaun M. Purcell,Digby Quested,Henrik B. Rasmussen,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Alan R. Sanders,Adam Savitz,Ulrich Schall,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Larry J. Seidman,Jianxin Shi,Jeremy M. Silverman,Jeremy M. Silverman,Jordan W. Smoller,Jordan W. Smoller,Erik Söderman,Chris C. A. Spencer,Eli A. Stahl,Eli A. Stahl,Eric Strengman,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Srinivas Thirumalai,Paul A. Tooney,Juha Veijola,Peter M. Visscher,John L. Waddington,Dermot Walsh,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Brandon Wormley,Naomi R. Wray,Jing Qin Wu,Clement C. Zai,Clement C. Zai,Rolf Adolfsson,Ole A. Andreassen,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Sven Cichon,David A. Collier,David A. Collier,Aiden Corvin,Mark J. Daly,Mark J. Daly,Ariel Darvasi,Enrico Domenici,Enrico Domenici,Tõnu Esko,Pablo V. Gejman,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Jo Knight,Douglas F. Levinson,Qingqin Li,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Bryan J. Mowry,Markus M. Nöthen,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pamela Sklar,David St Clair,James T.R. Walters,Thomas Werge,Thomas Werge,Thomas Werge,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan,Michael Conlon O'Donovan,Stephen W. Scherer,Benjamin M. Neale,Jonathan Sebat +329 more
TL;DR: In this article, a centralized analysis pipeline was applied to a SCZ cohort of 21,094 cases and 20,227 controls, and a global enrichment of copy number variants (CNVs) was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10-15), which persisted after excluding loci implicated in previous studies.