M
Maria Lazarou
Researcher at University of Nottingham
Publications - 3
Citations - 197
Maria Lazarou is an academic researcher from University of Nottingham. The author has contributed to research in topics: Plasmodium falciparum & Antibody. The author has an hindex of 3, co-authored 3 publications receiving 191 citations. Previous affiliations of Maria Lazarou include Liverpool School of Tropical Medicine.
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Journal ArticleDOI
The Importance of Human FcγRI in Mediating Protection to Malaria
Richard S. McIntosh,Jianguo Shi,Richard M. Jennings,Jonathan C Chappel,Jonathan C Chappel,Tania F. de Koning-Ward,Timothy P. L. Smith,Judith L. Green,Marjolein van Egmond,Jeanette H. W. Leusen,Maria Lazarou,Jan G. J. van de Winkel,Jan G. J. van de Winkel,Tarran S Jones,Brendan S. Crabb,Anthony A. Holder,Richard J. Pleass +16 more
TL;DR: This work describes the development of fully human antibodies specific for Plasmodium falciparum by antibody repertoire cloning from phage display libraries generated from immune Gambian adults, and documents the capacity of FcγRI to mediate potent antimalaria immunity and supports theDevelopment of F cγRI-directed therapy for human malaria.
Journal ArticleDOI
Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.
Graham Whyteside,Marcos J. C. Alcocer,Janet R. Kumita,Christopher M. Dobson,Maria Lazarou,Maria Lazarou,Richard J. Pleass,Richard J. Pleass,David B. Archer +8 more
TL;DR: The hypothesis that less stable proteins are targeted for degradation over secretion and that this accounts for the decrease in the yields observed is supported.
Journal ArticleDOI
Inhibition of Erythrocyte Invasion and Plasmodium falciparum Merozoite Surface Protein 1 Processing by Human Immunoglobulin G1 (IgG1) and IgG3 Antibodies
Maria Lazarou,José A. Guevara Patiño,Richard M. Jennings,Richard S. McIntosh,Jianguo Shi,Steven Howell,Eilish Cullen,Tarran S. Jones,Jaime Raúl Adame-Gallegos,Jonathan A. Chappel,Jana S. McBride,Michael J. Blackman,Anthony A. Holder,Richard J. Pleass +13 more
TL;DR: Human chimeric Abs constructed by using sequences, which combine the original mouse V regions with human γ1 and γ3 constant regions, retain the ability to bind to both parasites and recombinant MSP119, and both chimeric human immunoglobulin G1s (IgG1s) were at least as good at inhibiting erythrocyte invasion as the parental murine MAbs 12.10.