T
Timothy P. L. Smith
Researcher at Agricultural Research Service
Publications - 251
Citations - 18105
Timothy P. L. Smith is an academic researcher from Agricultural Research Service. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 58, co-authored 229 publications receiving 15972 citations. Previous affiliations of Timothy P. L. Smith include United States Department of Agriculture & University of Nottingham.
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Journal ArticleDOI
Mutations in myostatin (GDF8) in Double-Muscled Belgian Blue and Piedmontese Cattle
TL;DR: It appears likely that the mh allele in these breeds involves mutation within theMyostatin gene and that myostatin is a negative regulator of muscle growth in cattle as well as mice.
Journal ArticleDOI
The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
Christine G. Elsik,Christine G. Elsik,Christine G. Elsik,Ross L. Tellam,Kim C. Worley,Kim C. Worley,Richard A. Gibbs,Donna M. Muzny,George M. Weinstock,George M. Weinstock,David L. Adelson,Evan E. Eichler,Evan E. Eichler,Laura Elnitski,Roderic Guigó,Debora L. Hamernik,Steve M. Kappes,Harris A. Lewin,David J. Lynn,Frank W. Nicholas,Alexandre Reymond,Monique Rijnkels,Loren C. Skow,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Evgeny M. Zdobnov,Lawrence B. Schook,James E. Womack,Tyler Alioto,Stylianos E. Antonarakis,Alex Astashyn,Charles E. Chappie,Hsiu Chuan Chen,Jacqueline Chrast,Francisco Câmara,Olga Ermolaeva,Charlotte N. Henrichsen,Wratko Hlavina,Yuri Kapustin,Boris Kiryutin,Paul Kitts,Felix Kokocinski,Melissa J. Landrum,Donna Maglott,Kim D. Pruitt,Victor Sapojnikov,Stephen M. J. Searle,Victor V. Solovyev,Alexandre Souvorov,Catherine Ucla,Carine Wyss,Juan Manuel Anzola,Daniel Gerlach,Daniel Gerlach,Eran Elhaik,Eran Elhaik,Dan Graur,Justin T. Reese,Robert C. Edgar,John C. McEwan,Gemma Marie Payne,Joy M. Raison,Thomas Junier,Thomas Junier,Evgenia V. Kriventseva,Eduardo Eyras,Mireya Plass,Ravikiran Donthu,Denis M. Larkin,James M. Reecy,Mary Qu Yang,Lin Chen,Ze Cheng,Carol G. Chitko-McKown,George E. Liu,Lakshmi K. Matukumalli,Lakshmi K. Matukumalli,Jiuzhou Song,Bin Zhu,Daniel G. Bradley,Fiona S. L. Brinkman,Lilian P.L. Lau,Matthew D. Whiteside,Angela K. Walker,Thomas T. Wheeler,Theresa Casey,J. Bruce German,J. Bruce German,Danielle G. Lemay,Nauman J. Maqbool,A.J. Molenaar,Seongwon Seo,Paul Stothard,Cynthia L. Baldwin,R. Baxter,Candice L. Brinkmeyer-Larigford,Wendy C. Brown,Christopher P. Childers,Timothy Connelley,Shirley A. Ellis,Krista L. Fritz,Elizabeth Glass,Carolyn T.A. Herzig,Antti Livanainen,Kevin K. Lahmers,Anna K. Bennett,C. Michael Dickens,James G. R. Gilbert,Darren E. Hagen,Hanni Salih,Jan Aerts,Alexandre Rodrigues Caetano,Brian P. Dalrymple,José Fernando Garcia,Clare A. Gill,Stefan Hiendleder,Erdogan Memili,D.M. Spurlock,John L. Williams,Lee Alexander,Michael J. Brownstein,Le Luo Guan,Robert A. Holt,Steven J.M. Jones,Marco A. Marra,Richard A. Moore,Stephen S. Moore,Andrew J. Roberts,Masaaki Taniguchi,Masaaki Taniguchi,Richard C. Waterman,Joseph Chacko,Mimi M. Chandrabose,Andy Cree,Marvin Diep Dao,Huyen Dinh,Ramatu Ayiesha Gabisi,Sandra Hines,Jennifer Hume,Shalini N. Jhangiani,Vandita Joshi,Christie Kovar,Lora Lewis,Yin Shin Liu,John Lopez,Margaret Morgan,Ngoc Nguyen,Geoffrey Okwuonu,San Juana Ruiz,Jireh Santibanez,Rita A. Wright,Christian J. Buhay,Yan Ding,Shannon Dugan-Rocha,Judith Herdandez,Michael Holder,Aniko Sabo,Amy Egan,Jason Goodell,Katarzyna Wilczek-Boney,Gerald R. Fowler,Matthew Hitchens,Ryan J. Lozado,Charles Moen,David Steffen,James T. Warren,Jingkun Zhang,Readman Chiu,Jacqueline E. Schein,K. James Durbin,K. James Durbin,Paul Havlak,Paul Havlak,Huaiyang Jiang,Yue Liu,Xiang Qin,Yanru Ren,Yufeng Shen,Yufeng Shen,Henry Song,Stephanie Bell,Clay Davis,Angela Jolivet Johnson,Sandra L. Lee,Lynne V. Nazareth,Bella Mayurkumar Patel,Ling Ling Pu,Selina Vattathil,Rex Lee Williams,Stacey M. Curry,Cerissa Hamilton,Erica Sodergren,Erica Sodergren,David A. Wheeler,Wes Barris,Gary L. Bennett,André Eggen,Ronnie D. Green,Gregory P. Harhay,Matthew Hobbs,Oliver C. Jann,John W. Keele,Matthew Peter Kent,Sigbjam Lien,Stephanie D. McKay,Sean McWilliam,Abhirami Ratnakumar,Robert D. Schnabel,Timothy P. L. Smith,Warren M. Snelling,Tad S. Sonstegard,Roger T. Stone,Yoshikazu Sugimoto,Akiko Takasuga,Jeremy F. Taylor,Curtis P. Van Tassell,Michael D. MacNeil,A.R.R. Abatepaulo,Colette A. Abbey,Virpi Ahola,Lassudara G. Almeida,Ariel Fernando Amadio,Elen Anatriello,Suria M. Bahadue,Fernando H. Biase,Clayton R. Boldt,Jeffery A. Carroll,W. A. Carvalho,Eliane P. Cervelatti,Elsa Chacko,Jennifer E. Chapin,Ye Cheng,Jung-Woo Choi,Adam J. Colley,Tatiana A. DeCampos,Marcos De Donato,Isabel Kinney Ferreira de Miranda Santos,Carlo José Freire de Oliveira,Heather M Deobald,Eve Devinoy,Kaitlin E. Donohue,Peter Dove,Annett Eberlein,Carolyn Fitzsimmons,Alessandra Mara Franzin,Gustavo Garcia,Sem Genini,Cody J. Gladney,Jason R. Grant,Marion L. Greaser,Jonathan A. Green,Darryl L. Hadsell,Hatam A. Hakimov,Rob Halgren,Jennifer Harrow,E. Hart,N. Hastings,Marta Hernández,Zhi-Liang Hu,Antti Iivanainen,Aaron Ingham,Terhi Iso-Touru,Catherine Jamis,Kirsty Jensen,Dimos Kapetis,Tovah Kerr,Sari S. Khalil,Hasan Khatib,D. Kolbehdari,D. Kolbehdari,Cham G. Kumar,Dinesh Kumar,Richard J. Leach,Justin C. Lee,Changxi Li,Krystin M. Logan,Roberto Malinverni,E. Marques,William F. Martin,Natália F. Martins,Sandra Regina Maruyama,Raffaele Mazza,Kim L. McLean,Juan F. Medrano,Barbara T. Moreno,Daniela D. Moré,Carl T. Muntean,Hari Prasad Nandakumar,Marcelo Fábio Gouveia Nogueira,Ingrid Olsaker,Sameer D. Pant,Francesca Panzitta,Rosemeire Conceição Parra Pastor,Mario Andres Poli,Nathan Poslusny,Satyanarayana Rachagani,Shoba Ranganathan,Shoba Ranganathan,Andrej Razpet,Penny K. Riggs,Gonzalo Rincon,Nelida Rodriguez-Osorio,Nelida Rodriguez-Osorio,Sandra L. Rodriguez-Zas,Natasha E. Romero,Anne G. Rosenwald,Lillian Sando,Sheila M. Schmutz,Libing Shen,Laura Sherman,Bruce R. Southey,Ylva Strandberg Lutzow,Jonathan V. Sweedler,Imke Tammen,Bhanu Prakash V.L. Telugu,Jennifer M. Urbanski,Yuri Tani Utsunomiya,Chris P. Verschoor,Ashley J. Waardenberg,Zhiquan Wang,Robert Ward,Rosemarie Weikard,Thomas H. Welsh,Stephen N. White,Stephen N. White,Laurens G. Wilming,Kris R. Wunderlich,Jianqi Yang,Feng-Qi Zhao +328 more
TL;DR: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage and provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
Journal ArticleDOI
Development and Characterization of a High Density SNP Genotyping Assay for Cattle
Lakshmi K. Matukumalli,Lakshmi K. Matukumalli,Cindy Lawley,Robert D. Schnabel,Jeremy F. Taylor,M. F. Allan,Michael P. Heaton,Jeff O'Connell,Jeff O'Connell,Stephen S. Moore,Timothy P. L. Smith,Tad S. Sonstegard,Curtis P. Van Tassell +12 more
TL;DR: The BovineSNP50 assay as mentioned in this paper is a custom genotyping assay for cattle that interrogates 54,001 SNP loci to support genome-wide association (GWA) applications in cattle.
Journal ArticleDOI
Genome-Wide Survey of SNP Variation Uncovers the Genetic Structure of Cattle Breeds
Richard A. Gibbs,Jeremy F. Taylor,Curtis P. Van Tassell,William Barendse,William Barendse,Kellye Eversole,Clare A. Gill,Ronnie D. Green,Debora L. Hamernik,Steven M. Kappes,Sigbjørn Lien,Lakshmi K. Matukumalli,Lakshmi K. Matukumalli,John C. McEwan,Lynne V. Nazareth,Robert D. Schnabel,George M. Weinstock,David A. Wheeler,Paolo Ajmone-Marsan,Paul Boettcher,Alexandre Rodrigues Caetano,José Fernando Garcia,José Fernando Garcia,Olivier Hanotte,Paola Mariani,Loren C. Skow,Tad S. Sonstegard,John L. Williams,John L. Williams,Boubacar Diallo,Lemecha Hailemariam,Mário Luiz Martinez,C. A. Morris,Luiz Otávio Campos da Silva,Richard J. Spelman,Woudyalew Mulatu,Keyan Zhao,Colette A. Abbey,Morris Agaba,Flábio R. Araújo,Rowan J. Bunch,Rowan J. Bunch,James O. Burton,C. Gorni,Hanotte Olivier,Blair E. Harrison,Blair E. Harrison,Bill Luff,Marco Antonio Machado,Joel Mwakaya,Graham Plastow,Warren Sim,Warren Sim,Timothy P. L. Smith,Merle B Thomas,Merle B Thomas,Alessio Valentini,Paul D. Williams,James E. Womack,John Woolliams,Yue Liu,Xiang Qin,Kim C. Worley,Chuan Gao,Huaiyang Jiang,Stephen S. Moore,Yanru Ren,Xingzhi Song,Carlos Bustamante,Ryan D. Hernandez,Donna M. Muzny,Shobha Patil,Anthony San Lucas,Qing Fu,Matthew Peter Kent,Richard Vega,Aruna Matukumalli,Sean McWilliam,Sean McWilliam,Gert Sclep,Katarzyna Bryc,Jung-Woo Choi,Hong Gao,John J. Grefenstette,Brenda M. Murdoch,Alessandra Stella,Rafael Villa-Angulo,Mark G. Wright,Jan Aerts,Jan Aerts,Oliver C. Jann,Riccardo Negrini,Michael E. Goddard,Michael E. Goddard,Ben J. Hayes,Daniel G. Bradley,Marcos V.B. da Silva,Marcos V.B. da Silva,Lilian P.L. Lau,George E. Liu,David J. Lynn,David J. Lynn,Francesca Panzitta,Ken G. Dodds +103 more
TL;DR: Data show that cattle have undergone a rapid recent decrease in effective population size from a very large ancestral population, possibly due to bottlenecks associated with domestication, selection, and breed formation.
Journal ArticleDOI
Design of a High Density SNP Genotyping Assay in the Pig Using SNPs Identified and Characterized by Next Generation Sequencing Technology
A. M. Ramos,Richard P. M. A. Crooijmans,Nabeel A. Affara,Andreia J. Amaral,Alan Archibald,Jonathan E. Beever,Christian Bendixen,Carol Churcher,Richard Clark,Patrick Dehais,Mark Hansen,Jakob Hedegaard,Zhi-Liang Hu,Hindrik H. D. Kerstens,Andy Law,Hendrik-Jan Megens,Denis Milan,D. J. Nonneman,Gary A. Rohrer,Max F. Rothschild,Timothy P. L. Smith,Robert D. Schnabel,Curt P. Van Tassell,Jeremy F. Taylor,Ralph T Wiedmann,Lawrence B. Schook,Martien A. M. Groenen +26 more
TL;DR: The results of this study indicate the utility of using next generation sequencing technologies to identify large numbers of reliable SNPs and demonstrate that the PorcineSNP60 Beadchip is an excellent tool that will likely be used in a variety of future studies in pigs.