J
Judith L. Green
Researcher at Francis Crick Institute
Publications - 47
Citations - 2499
Judith L. Green is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Plasmodium falciparum & Gene. The author has an hindex of 28, co-authored 44 publications receiving 2245 citations. Previous affiliations of Judith L. Green include National Institute for Medical Research & Queen Mary University of London.
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Journal ArticleDOI
A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites.
Jake Baum,Dave Richard,Julie Healer,Melanie Rug,Zita Krnajski,Tim-Wolf Gilberger,Judith L. Green,Anthony A. Holder,Alan F. Cowman +8 more
TL;DR: Conservation of the motor complex suggests that a common molecular mechanism underlies all Apicomplexan motility, which highlights a number of novel targets for drug intervention to treat major diseases of humans and livestock.
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The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase.
Judith L. Green,Roxanne R. Rees-Channer,Stephen A. Howell,Stephen R. Martin,Ellen Knuepfer,Helen M. Taylor,Munira Grainger,Anthony A. Holder +7 more
TL;DR: Both C DPK1 activity and host cell invasion can be inhibited by the kinase inhibitor K252a, suggesting that CDPK1 is a suitable target for antimalarial drug development.
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Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion
Mahmood M. Alam,Lev Solyakov,Andrew R. Bottrill,Christian Flueck,Faiza Amber Siddiqui,Shailja Singh,Sharad Mistry,Maria Viskaduraki,Kate D. Lee,Christine S. Hopp,Chetan E. Chitnis,Christian Doerig,Robert W. Moon,Judith L. Green,Anthony A. Holder,David A. Baker,Andrew B. Tobin +16 more
TL;DR: The phosphorylation sites on 69 proteins involved in cell signalling, proteolysis, gene regulation, protein export and ion and protein transport are identified, indicating that cGMP/PfPKG acts as a signalling hub that plays a central role in a number of core parasite processes.
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The Plasmodium falciparum schizont phosphoproteome reveals extensive phosphatidylinositol and cAMP-protein kinase A signaling.
Edwin Lasonder,Judith L. Green,Grazia Camarda,Hana Talabani,Anthony A. Holder,Gordon Langsley,Pietro Alano +6 more
TL;DR: This study reveals the coinvolvement of PKA, further implicating cAMP as an important regulator of host cell invasion and cAMP-PKA signaling is implicated in a wide variety of processes including motility.
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The Importance of Human FcγRI in Mediating Protection to Malaria
Richard S. McIntosh,Jianguo Shi,Richard M. Jennings,Jonathan C Chappel,Jonathan C Chappel,Tania F. de Koning-Ward,Timothy P. L. Smith,Judith L. Green,Marjolein van Egmond,Jeanette H. W. Leusen,Maria Lazarou,Jan G. J. van de Winkel,Jan G. J. van de Winkel,Tarran S Jones,Brendan S. Crabb,Anthony A. Holder,Richard J. Pleass +16 more
TL;DR: This work describes the development of fully human antibodies specific for Plasmodium falciparum by antibody repertoire cloning from phage display libraries generated from immune Gambian adults, and documents the capacity of FcγRI to mediate potent antimalaria immunity and supports theDevelopment of F cγRI-directed therapy for human malaria.