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Anthony A. Holder
Researcher at Francis Crick Institute
Publications - 336
Citations - 23132
Anthony A. Holder is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Plasmodium falciparum & Plasmodium yoelii. The author has an hindex of 78, co-authored 328 publications receiving 21733 citations. Previous affiliations of Anthony A. Holder include University of Edinburgh & University of Dundee.
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A proteomic view of the Plasmodium falciparum life cycle
Laurence Florens,Michael P. Washburn,J. Dale Raine,Robert M. Anthony,Munira Grainger,J. David Haynes,J. David Haynes,J. Kathleen Moch,Nemone Muster,John B. Sacci,John B. Sacci,David L. Tabb,David L. Tabb,Adam A. Witney,Adam A. Witney,Dirk Wolters,Dirk Wolters,Yimin Wu,Malcolm J. Gardner,Anthony A. Holder,Robert E. Sinden,John R. Yates,John R. Yates,Daniel J. Carucci +23 more
TL;DR: A high-throughput proteomics approach was applied to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite.
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Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle
Karine G. Le Roch,Yingyao Zhou,Peter L. Blair,Muni Grainger,J. Kathleen Moch,J. David Haynes,Patricia de la Vega,Anthony A. Holder,Serge Batalov,Daniel J. Carucci,Elizabeth A. Winzeler,Elizabeth A. Winzeler +11 more
TL;DR: A high-density oligonucleotide array is used to generate expression profiles of human and mosquito stages of the malaria parasite's life cycle and finds genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes.
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A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.
TL;DR: A complex of polypeptides derived from a precursor is present on the surface of the malaria merozoite and only a small fragment is retained on the parasite surface and carried into the newly infected red cell.
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Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle
Karine G. Le Roch,Jeffrey R. Johnson,Laurence Florens,Yingyao Zhou,Andrey Santrosyan,Munira Grainger,S. Frank Yan,Kim C. Williamson,Anthony A. Holder,Daniel J. Carucci,John R. Yates,Elizabeth A. Winzeler +11 more
TL;DR: Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.
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Immunization against blood-stage rodent malaria using purified parasite antigens.
TL;DR: It is reported here that mice immunized with either a 235,000 apparent molecular weight merozoite-specific protein or a 230,000 MW schizont protein and its proteolytic derivatives were protected against infection with P. y.