M
Maria Leonido-Yee
Researcher at University of California, Los Angeles
Publications - 10
Citations - 2137
Maria Leonido-Yee is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Magnetic resonance imaging & Cerebral blood flow. The author has an hindex of 8, co-authored 10 publications receiving 2060 citations. Previous affiliations of Maria Leonido-Yee include Brookhaven National Laboratory.
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Journal ArticleDOI
Association of Dopamine Transporter Reduction With Psychomotor Impairment in Methamphetamine Abusers
Nora D. Volkow,Linda Chang,Gene-Jack Wang,Joanna S. Fowler,Maria Leonido-Yee,Dinko Franceschi,Mark J. Sedler,S. John Gatley,Robert Hitzemann,Yu-Shin Ding,Jean Logan,Christopher Wong,Eric N. Miller +12 more
TL;DR: Evidence is provided that methamphetamine at dose levels taken by human abusers of the drug leads to dopamine transporter reduction that is associated with motor and cognitive impairment and the urgency of alerting clinicians and the public of the long-term changes that methamphetamine can induce in the human brain.
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Evidence for long-term neurotoxicity associated with methamphetamine abuse A 1H MRS study
TL;DR: Evidence for long-term neuronal damage in abstinent methamphetamine users is provided by the reduced N-acetylaspartate on 1H MRS, which was reduced significantly in the basal ganglia and frontal white matter of methamphetamine users compared with control subjects.
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Cerebral metabolite abnormalities correlate with clinical severity of HIV-1 cognitive motor complex
TL;DR: In early stages of HIV–CMC, frontal white matter showed evidence of glial proliferation and cell membrane injury, but no significant neuronal injury, while HIV–MCMD and HIV–dementia patients have different neurochemical abnormalities.
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Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia.
Linda Chang,Thomas Ernst,Maria Leonido-Yee,Mallory D. Witt,Oliver Speck,Irwin Walot,Eric N. Miller +6 more
TL;DR: 1H MRS detects improvement of brain injury measured by cerebral metabolites, particularly the glial marker [MI], in patients with early HIV-CMC after HAART, in addition to systemic measures of HIV infection.
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Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users.
Linda Chang,Thomas Ernst,Thomas Ernst,Oliver Speck,Oliver Speck,Hetal Patel,Menaka DeSilva,Maria Leonido-Yee,Eric N. Miller +8 more
TL;DR: It is suggested that METH abuse is associated with persistent physiologic changes in the brain, and these changes are accompanied by slower reaction times on computerized measures of cognitive function.