M
Maria Orietta Borghi
Researcher at University of Milan
Publications - 160
Citations - 5029
Maria Orietta Borghi is an academic researcher from University of Milan. The author has contributed to research in topics: Antiphospholipid syndrome & Antibody. The author has an hindex of 40, co-authored 151 publications receiving 4386 citations.
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Journal ArticleDOI
Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
Elena Raschi,Cinzia Testoni,Daniela Bosisio,Maria Orietta Borghi,Takao Koike,Alberto Mantovani,Pier Luigi Meroni +6 more
TL;DR: It is demonstrated that anti-beta(2)-GPI antibodies react with their antigen likely associated to a member of the TLR/IL-1 receptor family on the EC surface and directly induce activation, suggesting an involvement of the toll-like receptor (TLR) family.
Journal ArticleDOI
Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms.
Silvia S. Pierangeli,Pojen P. Chen,Elena Raschi,Silvia Scurati,Claudia Grossi,Maria Orietta Borghi,Iván Palomo,E. Nigel Harris,Pier Luigi Meroni +8 more
TL;DR: This article addresses molecular events triggered by aPL Abs on endothelial cells, platelets, and monocytes and complement activation, as well as a review of the current knowledge with regard to the putative receptor(s) recognized by a PL Abs on target cells aswell as novel mechanisms that involve fibrinolytic processes.
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Toll‐like receptor and antiphospholipid mediated thrombosis: in vivo studies
Silvia S. Pierangeli,Mariano Vega-Ostertag,Elena Raschi,Xiaowei Liu,Zurina Romay-Penabad,Valeria De Micheli,Monica Galli,Marco Moia,Angela Tincani,Maria Orietta Borghi,Tracy U. Nguyen-Oghalai,Pier Luigi Meroni +11 more
TL;DR: Findings in LPS−/− mice and the reduction in the “protective” polymorphism in patients with APS with thrombosis suggest that TLR-4 is involved in the interaction of aPL with endothelial cells in vivo.
Journal Article
Relationship between anti-phospholipid and anti-endothelial cell antibodies III: beta 2 glycoprotein I mediates the antibody binding to endothelial membranes and induces the expression of adhesion molecules.
N. Del Papa,L Guidali,L Spatola,Bonara P,Maria Orietta Borghi,Angela Tincani,G. Balestrieri,Pier Luigi Meroni +7 more
TL;DR: Findings indicate that the close association between anti-endothelial and anti-phospholipid antibodies is sustained by antibodies which recognize beta 2 GPI adhering to the endothelial cells, and can promote their activation.
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TH1 and TH2 cytokine production by peripheral blood mononuclear cells from HIV-infected patients
Wilma Barcellini,G P Rizzardi,Maria Orietta Borghi,C. Fain,Adriano Lazzarin,Pier Luigi Meroni +5 more
TL;DR: In the course of HIV disease mitogen-stimulated IL-2 production decreased, spontaneous and stimulated IL-6 production and spontaneous IL-10 secretion increased, and a switch from a type 1 to a type 2 response occurs in HIV infection.