C
Cinzia Testoni
Researcher at University of Milan
Publications - 21
Citations - 1745
Cinzia Testoni is an academic researcher from University of Milan. The author has contributed to research in topics: Endothelial stem cell & Beta 2-Glycoprotein I. The author has an hindex of 16, co-authored 21 publications receiving 1700 citations. Previous affiliations of Cinzia Testoni include University of Basel.
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Journal ArticleDOI
Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
Elena Raschi,Cinzia Testoni,Daniela Bosisio,Maria Orietta Borghi,Takao Koike,Alberto Mantovani,Pier Luigi Meroni +6 more
TL;DR: It is demonstrated that anti-beta(2)-GPI antibodies react with their antigen likely associated to a member of the TLR/IL-1 receptor family on the EC surface and directly induce activation, suggesting an involvement of the toll-like receptor (TLR) family.
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Statins prevent endothelial cell activation induced by antiphospholipid (anti–β2-glycoprotein I) antibodies: Effect on the proadhesive and proinflammatory phenotype
Pier L. Meroni,Elena Raschi,Cinzia Testoni,Angela Tincani,Genesio Balestrieri,Raffaella Molteni,Munther A. Khamashta,Elena Tremoli,Marina Camera +8 more
TL;DR: Endothelial activation mediated by anti-beta2GPI antibody can be inhibited by statins, and this data provide a rationale for using statins as an additional therapeutic tool in APS.
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Anti-C1q antibodies may help in diagnosing a renal flare in lupus nephritis.
Gabriella Moroni,Marten Trendelenburg,Nicoletta Del Papa,Silvana Quaglini,Elena Raschi,Paola Panzeri,Cinzia Testoni,Angela Tincani,Giovanni Banfi,Genesio Balestrieri,J A Schifferli,Pier Luigi Meroni,Claudio Ponticelli +12 more
TL;DR: In patients with biopsy-proven lupus nephritis, anti-C1q Ab titers appear to be strongly related to renal disease activity, and their measurement may be useful for confirming the diagnosis of renal flares of lupu nephitis.
Journal ArticleDOI
Endothelial activation by aPL: a potential pathogenetic mechanism for the clinical manifestations of the syndrome.
Pier Luigi Meroni,Elena Raschi,Marina Camera,Cinzia Testoni,Ferdinando Nicoletti,A Tincani,Munther A. Khamashta,G Balestrieri,Elena Tremoli,David C. Hess +9 more
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Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis.
Carlo Chizzolini,Elena Raschi,Roger Rezzonico,Cinzia Testoni,Roberto Mallone,Armando Gabrielli,Andrea Facchini,Nicoletta Del Papa,Maria Orietta Borghi,Jean-Michel Dayer,Pier Luigi Meroni +10 more
TL;DR: Findings confirm the presence of AFAs in SSc sera and demonstrate, for the first time, that autoantibodies reacting with fibroblasts surface molecules act as an extrinsic stimulus inducing fibroblast activation in vitro.