M
Maria Ouzounova
Researcher at Georgia Regents University
Publications - 27
Citations - 1097
Maria Ouzounova is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Cancer stem cell & Metastasis. The author has an hindex of 14, co-authored 22 publications receiving 822 citations. Previous affiliations of Maria Ouzounova include University of Michigan & University of Lyon.
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Journal ArticleDOI
Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade
Maria Ouzounova,Eunmi Lee,Raziye Piranlioglu,Abdeljabar El Andaloussi,Ravindra Kolhe,Mehmet F. Demirci,Daniela Marasco,Iskander Asm,Ahmed Chadli,Khaled A. Hassan,Muthusamy Thangaraju,Gang Zhou,Ali S. Arbab,John K. Cowell,Hasan Korkaya +14 more
TL;DR: It is demonstrated here that monocytic (mMDSC) and granulocytic subsets of myeloid-derived suppressor cells infiltrate in the primary tumour and distant organs with different time kinetics and regulate spatiotemporal tumour plasticity.
Journal ArticleDOI
MicroRNA miR-30 family regulates non-attachment growth of breast cancer cells.
Maria Ouzounova,Tri Vuong,Pierre-Benoit Ancey,Mylène Ferrand,Geoffroy Durand,Florence Le Calvez Kelm,Carlo M. Croce,Chantal Matar,Zdenko Herceg,Hector Hernandez-Vargas +9 more
TL;DR: This is the first analysis of target prediction in a whole family of microRNAs potentially involved in survival of putative BT-ICs, and shows that miR-30a regulates the growth of breast cancer cells in non-attachment conditions.
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Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity
Rosemarie C. D'Angelo,Maria Ouzounova,Maria Ouzounova,April Davis,Daejin Choi,Stevie M. Tchuenkam,Gwangil Kim,Tahra Luther,Ahmed A. Quraishi,Yasin Senbabaoglu,Sarah J. Conley,Shawn G. Clouthier,Khaled A. Hassan,Max S. Wicha,Hasan Korkaya,Hasan Korkaya +15 more
TL;DR: A molecular mechanism for the role of Notch-mediated regulation of breast CSCs is revealed and a compelling rationale for CSC-targeted therapeutics is provided.
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Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells
Hector Hernandez-Vargas,Maria Ouzounova,Florence Le Calvez-Kelm,Marie-Pierre Lambert,Sandrine McKay-Chopin,Sean V. Tavtigian,Alain Puisieux,Chantal Matar,Zdenko Herceg +8 more
TL;DR: The results show that Jak-STAT activation may represent a characteristic of putative breast cancer stem cells, and favor the concept that the expression of cancer stem-like pathways and the establishment and maintenance of defining properties ofcancer stem cells are orchestrated by epigenetic mechanisms.
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SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model
Gwangil Kim,Maria Ouzounova,Ahmed A. Quraishi,April Davis,Nader Tawakkol,Shawn G. Clouthier,Fayaz Malik,Amanda K. Paulson,Rosemarie C. D'Angelo,Sumeyye Korkaya,Trenton L. Baker,Elif Serap Esen,Aleix Prat,Suling Liu,Celina G. Kleer,Dafydd G. Thomas,Max S. Wicha,Hasan Korkaya +17 more
TL;DR: These studies uncover important connections between inflammation and carcinogenesis and suggest that blocking pro-inflammatory cytokines may be utilized as an attractive strategy to target triple negative breast tumors, which currently lacks molecularly targeted therapies.