Ahmed A. Quraishi

TL;DR: It is demonstrated that trastuzumab resistance may be mediated by an IL6 inflammatory loop and suggested that blocking this loop may provide alternative strategy to overcometrastuzuab resistance.

TL;DR: It is shown that HER2 is selectively expressed in and regulates self-renewal of the cancer stem cell (CSC) population in estrogen receptor-positive, HER2(-) luminal breast cancers, and a CSC model in which maximal clinical benefit is achieved when CSC targeting agents are administered in the adjuvant setting is supported.

TL;DR: A molecular mechanism for the role of Notch-mediated regulation of breast CSCs is revealed and a compelling rationale for CSC-targeted therapeutics is provided.

TL;DR: These studies uncover important connections between inflammation and carcinogenesis and suggest that blocking pro-inflammatory cytokines may be utilized as an attractive strategy to target triple negative breast tumors, which currently lacks molecularly targeted therapies.

TL;DR: The results suggest that interplay between genetic and epigenetic changes during malignant transformation of mammary epithelial cells may activate multiple signaling cascades and reconstitution of SOCS3 may have therapeutic utility in TNBC.