M
Maria Radanova
Researcher at Medical University of Varna
Publications - 34
Citations - 301
Maria Radanova is an academic researcher from Medical University of Varna. The author has contributed to research in topics: Autoantibody & Lupus nephritis. The author has an hindex of 7, co-authored 27 publications receiving 215 citations.
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Journal ArticleDOI
Functional Complement C1q Abnormality Leads to Impaired Immune Complexes and Apoptotic Cell Clearance
Lubka T. Roumenina,Lubka T. Roumenina,Lubka T. Roumenina,Damien Sène,Maria Radanova,Jacques Blouin,Lise Halbwachs-Mecarelli,Lise Halbwachs-Mecarelli,Marie-Agnès Dragon-Durey,Wolf H. Fridman,Véronique Frémeaux-Bacchi +10 more
TL;DR: The data infer that the binding of C1q to apoptotic cells in humans is insufficient to assure self-tolerance, and the opsonization capacity of C4 and C3 fragments has to be intact to fight infections and to prevent autoimmunity.
Journal ArticleDOI
Heme interacts with C1Q and inhibits the classical complement pathway
Lubka T. Roumenina,Lubka T. Roumenina,Lubka T. Roumenina,Maria Radanova,Boris P. Atanasov,Krastio T. Popov,Srini V. Kaveri,Srini V. Kaveri,Srini V. Kaveri,Sébastien Lacroix-Desmazes,Sébastien Lacroix-Desmazes,Sébastien Lacroix-Desmazes,Véronique Frémeaux-Bacchi,Jordan D. Dimitrov,Jordan D. Dimitrov,Jordan D. Dimitrov +15 more
TL;DR: The data suggest that heme is a natural negative regulator of the classical complement pathway at the level of C1q, and may play a role at sites of excessive tissue damage and hemolysis where large amounts of free heme are released.
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Anti-C1q autoantibodies specific against the globular domain of the C1qB-chain from patient with lupus nephritis inhibit C1q binding to IgG and CRP
TL;DR: Results appear to suggest that the anti-ghB autoantibodies may partially induce acquired functional C1q deficiency and thus may interfere with the biological function of C 1q.
Journal ArticleDOI
Detection of autoantibodies against the globular domain of human C1q in the sera of systemic lupus erythematosus patients.
TL;DR: Sera from SLE patients, containing high levels of anti-C1q antibodies, showed differentially increased binding towards ghA and ghB, which suggested that the gC1Q domain can also be target ofAnti-C 1q antibodies generated in Sle patients.
Journal ArticleDOI
Sarcopenia and high NLR are associated with the development of hyperprogressive disease after second‐line pembrolizumab in patients with non‐small‐cell lung cancer
Mila P. Petrova,Ivan Donev,Maria Radanova,Mariyana I. Eneva,Eleonora Dimitrova,Geogi N. Valchev,Velko Minchev,Margarita S. Taushanova,Marsella Boneva,Teodora Karanikolova,Radostina Gencheva,Georgi Zhbantov,Anika Ivanova,Constanta Timcheva,Boian Pavlov,Vera G. Megdanova,Bozhil Robev,Nikolay Conev +17 more
TL;DR: The data suggest that a high pre‐immunotherapy NLR2 and the presence of sarcopenia are potential risk factors for the development of HPD.