M
Maria Rohm
Researcher at University Hospital Heidelberg
Publications - 12
Citations - 497
Maria Rohm is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Cachexia & Cancer. The author has an hindex of 6, co-authored 11 publications receiving 298 citations. Previous affiliations of Maria Rohm include German Cancer Research Center & Heidelberg University.
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Journal ArticleDOI
Cancer Cachexia: More Than Skeletal Muscle Wasting
TL;DR: Recent developments elucidating the roles of different tissues as well as tissue crosstalk in this wasting syndrome are described, including potential links to other cancer-associated morbidities.
Journal ArticleDOI
An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice.
Maria Rohm,Michaela Schäfer,Victor Laurent,Bilgen Ekim Üstünel,Katharina Niopek,Carolyn Algire,Oksana Hautzinger,Tjeerd P. Sijmonsma,Annika Zota,Dasa Medrikova,Natalia S. Pellegata,Mikael Rydén,Agné Kulyté,Ingrid Dahlman,Peter Arner,Natasa Petrovic,Barbara Cannon,Ez-Zoubir Amri,Bruce E. Kemp,Bruce E. Kemp,Gregory R. Steinberg,Petra Janovska,Jan Kopecky,Christian Wolfrum,Matthias Blüher,Mauricio Berriel Diaz,Stephan Herzig +26 more
TL;DR: The UCP1-independent remodeling of adipocyte lipid homeostasis is established as a key event in tumor-induced WAT wasting, and the ACIP-dependent preservation of Ampk integrity in the WAT is proposed as a concept in future therapies for cachexia.
Journal ArticleDOI
Energy metabolism in cachexia
TL;DR: How energy enters the body and is utilized by the different organs, including the gut, liver, adipose tissue, and muscle, and how these organs contribute to the energy wasting observed in cachexia are discussed.
Journal ArticleDOI
TSC22D4 is a molecular output of hepatic wasting metabolism
Allan Jones,Kilian Friedrich,Maria Rohm,Michaela Schäfer,Carolyn Algire,Philipp Kulozik,Oksana Seibert,Karin Müller-Decker,Tjeerd P. Sijmonsma,Daniela Strzoda,Carsten Sticht,Norbert Gretz,Geesje M. Dallinga-Thie,Barbara Leuchs,Manfred Kögl,Wolfgang Stremmel,Mauricio Berriel Diaz,Stephan Herzig +17 more
TL;DR: Hepatic TSC22D4 activity may represent a molecular rationale for peripheral energy deprivation in subjects with metabolic wasting diseases, including cancer cachexia.
Journal ArticleDOI
Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia
Michaela Schäfer,Christian U. Oeing,Christian U. Oeing,Maria Rohm,Ezgi Baysal-Temel,Ezgi Baysal-Temel,Lorenz H. Lehmann,Lorenz H. Lehmann,Ralf Bauer,Ralf Bauer,H. Christian Volz,Michael Boutros,Daniela Sohn,Carsten Sticht,Norbert Gretz,Katrin Eichelbaum,Tessa Werner,Marc N. Hirt,Thomas Eschenhagen,Karin Müller-Decker,Oliver Strobel,Thilo Hackert,Jeroen Krijgsveld,Hugo A. Katus,Hugo A. Katus,Mauricio Berriel Diaz,Johannes Backs,Johannes Backs,Stephan Herzig +28 more
TL;DR: The identification of Ataxin-10 as part of a cachexokine cocktail now provides a rational approach towards personalized predictive, diagnostic and therapeutic measures in cancer cachexia.