C
Christian Wolfrum
Researcher at ETH Zurich
Publications - 204
Citations - 11064
Christian Wolfrum is an academic researcher from ETH Zurich. The author has contributed to research in topics: Adipose tissue & Adipocyte. The author has an hindex of 45, co-authored 178 publications receiving 8585 citations. Previous affiliations of Christian Wolfrum include Alnylam Pharmaceuticals & Rockefeller University.
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Journal ArticleDOI
Adipose-derived circulating miRNAs regulate gene expression in other tissues
Thomas Thomou,Marcelo A. Mori,Jonathan M. Dreyfuss,Jonathan M. Dreyfuss,Masahiro Konishi,Masaji Sakaguchi,Christian Wolfrum,Tata Nageswara Rao,Tata Nageswara Rao,Jonathon N. Winnay,Ruben Garcia-Martin,Steven K. Grinspoon,Phillip Gorden,C. Ronald Kahn +13 more
TL;DR: Transplantation of both white and brown adipose tissue—brown especially—into ADicerKO mice restores the level of numerous circulating miRNAs that are associated with an improvement in glucose tolerance and a reduction in hepatic Fgf21 mRNA and circulating FGF21.
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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
Christian Wolfrum,Shuanping Shi,K. Narayanannair Jayaprakash,Muthusamy Jayaraman,Gang Wang,Rajendra K. Pandey,Kallanthottathil G. Rajeev,Tomoko Nakayama,Klaus Charrise,Esther Ndungo,Tracy Zimmermann,Victor Koteliansky,Muthiah Manoharan,Markus Stoffel,Markus Stoffel,Markus Stoffel +15 more
TL;DR: It is shown that conjugation to bile acids and long-chain fatty acids, in addition to cholesterol, mediates siRNA uptake into cells and gene silencing in vivo and can be exploited to optimize therapeutic siRNA delivery.
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Bi-directional interconversion of brite and white adipocytes
TL;DR: It is shown here that cold-induced formation of brite adipocytes in mice is reversed within 5 weeks of warm adaptation, but the brITE adipocytes formed by cold stimulation are not eliminated.
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A family with severe insulin resistance and diabetes due to a mutation in AKT2.
Stella George,Justin J. Rochford,Christian Wolfrum,Sarah L. Gray,S Schinner,Jenny C Wilson,Maria A. Soos,Peter R. Murgatroyd,Rachel M. Williams,Carlo L. Acerini,David B. Dunger,David Barford,A. Margot Umpleby,Nicholas J. Wareham,Huw Alban Davies,Alan J. Schafer,Markus Stoffel,Stephen O'Rahilly,Inês Barroso,Inês Barroso +19 more
TL;DR: A mutation in the gene encoding the protein kinase AKT2/PKBβ in a family that shows autosomal dominant inheritance of severe insulin resistance and diabetes mellitus is described, demonstrating the central importance of AKT signaling to insulin sensitivity in humans.
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Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors α- and γ-mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus
TL;DR: In localization studies using laser-scanning microscopy, it is shown that L-FABP and PPARα colocalize in the nucleus of mouse primary hepatocytes and it is demonstrated that the observed interaction of both proteins is independent of ligand binding.