Marian C. Okondo

TL;DR: Bidirectional crosstalk between apoptosis and pyroptosis in monocytes and macrophages is revealed, further illuminating the complex interplay between cell death pathways in the innate immune system.

TL;DR: It is shown that the CARD-containing protein CARD8 mediates DPP8/9 inhibitor-induced pro-caspase-1-dependent pyroptosis in human myeloid cells, and indicates that its activation by small-molecule DPP 8/9 inhibitors represents a new potential therapeutic strategy for AML.

TL;DR: This study used genome-wide CRISPR-Cas9 knockout screens to identify genes required for NLRP1B-mediated pyroptosis and discovered that lethal factor induces cell death via the N-end rule proteasomal degradation pathway.

TL;DR: It is shown that Val-boroPro stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis and reveals a new checkpoint that controls the activation of the innate immune system.

TL;DR: This work reveals a previously unrecognized mechanism for activating an innate immune pattern recognition receptor and suggests that Dpp8/9 serve as an intracellular checkpoint to restrain Nlrp1b and the innate immune system.