C
Cornelius Y. Taabazuing
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 22
Citations - 1454
Cornelius Y. Taabazuing is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Pyroptosis & Inflammasome. The author has an hindex of 13, co-authored 17 publications receiving 850 citations. Previous affiliations of Cornelius Y. Taabazuing include University of Massachusetts Amherst & Howard Hughes Medical Institute.
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Journal ArticleDOI
Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages.
TL;DR: Bidirectional crosstalk between apoptosis and pyroptosis in monocytes and macrophages is revealed, further illuminating the complex interplay between cell death pathways in the innate immune system.
Journal ArticleDOI
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia
Darren C. Johnson,Cornelius Y. Taabazuing,Marian C. Okondo,Ashley J. Chui,Sahana D. Rao,Fiona C. Brown,Casie Reed,Elizabeth Peguero,Elisa de Stanchina,Alex Kentsis,Daniel A. Bachovchin,Daniel A. Bachovchin +11 more
TL;DR: It is shown that the CARD-containing protein CARD8 mediates DPP8/9 inhibitor-induced pro-caspase-1-dependent pyroptosis in human myeloid cells, and indicates that its activation by small-molecule DPP 8/9 inhibitors represents a new potential therapeutic strategy for AML.
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N-terminal degradation activates the NLRP1B inflammasome.
Ashley J. Chui,Marian C. Okondo,Sahana D. Rao,Kuo Gai,Andrew R. Griswold,Darren C. Johnson,Daniel P. Ball,Cornelius Y. Taabazuing,Elizabeth L. Orth,Brooke A. Vittimberga,Daniel A. Bachovchin,Daniel A. Bachovchin +11 more
TL;DR: This study used genome-wide CRISPR-Cas9 knockout screens to identify genes required for NLRP1B-mediated pyroptosis and discovered that lethal factor induces cell death via the N-end rule proteasomal degradation pathway.
Journal ArticleDOI
Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome.
Marian C. Okondo,Sahana D. Rao,Cornelius Y. Taabazuing,Ashley J. Chui,Sarah E. Poplawski,Darren C. Johnson,Daniel A. Bachovchin +6 more
TL;DR: This work reveals a previously unrecognized mechanism for activating an innate immune pattern recognition receptor and suggests that Dpp8/9 serve as an intracellular checkpoint to restrain Nlrp1b and the innate immune system.
Journal ArticleDOI
Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model
Jennifer S. Pfingsten,Karen J. Goodrich,Cornelius Y. Taabazuing,Faissal Ouenzar,Pascal Chartrand,Thomas R. Cech +5 more
TL;DR: It is demonstrated that deletions designed to constrict the DNA-binding ring of Ku80 disrupt nonhomologous end-joining (NHEJ), telomeric gene silencing, and telomere length maintenance, suggesting that these functions require Ku's DNA end-binding activity.