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Andrew R. Griswold
Researcher at Kettering University
Publications - 25
Citations - 924
Andrew R. Griswold is an academic researcher from Kettering University. The author has contributed to research in topics: Inflammasome & Pyroptosis. The author has an hindex of 9, co-authored 18 publications receiving 406 citations. Previous affiliations of Andrew R. Griswold include Cornell University & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
N-terminal degradation activates the NLRP1B inflammasome.
Ashley J. Chui,Marian C. Okondo,Sahana D. Rao,Kuo Gai,Andrew R. Griswold,Darren C. Johnson,Daniel P. Ball,Cornelius Y. Taabazuing,Elizabeth L. Orth,Brooke A. Vittimberga,Daniel A. Bachovchin,Daniel A. Bachovchin +11 more
TL;DR: This study used genome-wide CRISPR-Cas9 knockout screens to identify genes required for NLRP1B-mediated pyroptosis and discovered that lethal factor induces cell death via the N-end rule proteasomal degradation pathway.
Journal ArticleDOI
Iron(II)-Catalyzed Benzylic Fluorination
Steven Bloom,Cody Ross Pitts,Ryan Woltornist,Andrew R. Griswold,Maxwell Gargiulo Holl,Thomas Lectka +5 more
TL;DR: A mild, one-pot synthesis of monofluorinated benzylic substrates is reported with commercially available iron(II) acetylacetonate and Selectfluor in good to excellent yields and selectivity.
Journal ArticleDOI
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation
L. Robert Hollingsworth,L. Robert Hollingsworth,Humayun Sharif,Humayun Sharif,Andrew R. Griswold,Andrew R. Griswold,Pietro Fontana,Pietro Fontana,Julian Mintseris,Kevin B. Dagbay,Kevin B. Dagbay,Joao A. Paulo,Steven P. Gygi,Daniel A. Bachovchin,Daniel A. Bachovchin,Hao Wu,Hao Wu +16 more
TL;DR: In this paper, a ternary complex consisting of DPP9, full-length NLRP1, and the NLRPTCT was found to be a checkpoint for inflammasome activation.
Journal ArticleDOI
The NLRP1 and CARD8 inflammasomes.
Cornelius Y. Taabazuing,Andrew R. Griswold,Andrew R. Griswold,Daniel A. Bachovchin,Daniel A. Bachovchin +4 more
TL;DR: The danger‐associated stimuli that have been reported to activate NLRP1 and/or CARD8 are reviewed, including anthrax lethal toxin, Toxoplasma gondii, Shigella flexneri and the small molecule DPP8/9 inhibitor Val‐boroPro, focusing on recent mechanistic insights and highlighting unresolved questions.
Journal ArticleDOI
Caspase-1 interdomain linker cleavage is required for pyroptosis
Daniel P. Ball,Cornelius Y. Taabazuing,Andrew R. Griswold,Elizabeth L. Orth,Sahana D. Rao,Ilana B. Kotliar,Lauren E Vostal,Darren C. Johnson,Daniel A. Bachovchin,Daniel A. Bachovchin +9 more
TL;DR: It is discovered that both the NLRP1 and CARD8 inflammasomes require pro-caspase-1 autoproteolysis between the small and large catalytic subunits to induce pyroptosis, identifying CARD8 as the first canonicalinflammasome-forming PRR that does not form an ASC-containing signaling platform.