M
Mariastella Zannini
Researcher at National Research Council
Publications - 77
Citations - 4874
Mariastella Zannini is an academic researcher from National Research Council. The author has contributed to research in topics: Transcription factor & PAX8. The author has an hindex of 32, co-authored 76 publications receiving 4573 citations. Previous affiliations of Mariastella Zannini include European Bioinformatics Institute & Stazione Zoologica Anton Dohrn.
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Journal ArticleDOI
Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation
Antimo Migliaccio,Gabriella Castoria,Marina Di Domenico,Antonietta de Falco,Antonio Bilancio,Maria Lombardi,Maria Vittoria Barone,Donatella Ametrano,Mariastella Zannini,Ciro Abbondanza,Ferdinando Auricchio +10 more
TL;DR: Hormone‐stimulated Src interaction with the androgen receptor and oestradiol receptor α or β is detected using glutathione S‐transferase fusion constructs and the role of this phosphotyrosine is stressed by its requirement for association of oestrogens receptor α with Src and consequent activation of Src in intact Cos cells.
Journal ArticleDOI
Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters.
TL;DR: The Pax-8 protein binds, through its paired domain, to the promoters of thyroglobulin and thyroperoxidase, genes that are exclusively expressed in the thyroid, representing the first identified natural targets for transcriptional activation by a paired domain-containing protein.
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TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation
Mariastella Zannini,Virginia Avantaggiato,Elio Biffali,Maria Ina Arnone,Koichi Sato,Michele Pischetola,B. A. Taylor,S. J. Phillips,Antonio Simeone,R Di Lauro +9 more
TL;DR: The cloning of TTF‐2 is reported, a DNA binding protein that recognizes sites on both Tg and TPO promoters that shows transient expression in the developing thyroid and anterior pituitary and suggests that this transcription factor plays the role in development of a negative controller of thyroid‐specific gene expression.
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The Paired-Domain Transcription Factor Pax8 Binds to the Upstream Enhancer of the Rat Sodium/Iodide Symporter Gene and Participates in Both Thyroid-Specific and Cyclic-AMP-Dependent Transcription
TL;DR: The presence of an enhancer that is located between nucleotides −2264 and −2495 in the 5′-flanking region of the NIS gene and that recapitulates the most relevant aspects of NIS regulation is demonstrated, suggesting that this enhancer could represent a novel type of cAMP responsive element.
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Pax8 has a key role in thyroid cell differentiation
Marina Pasca di Magliano,Marina Pasca di Magliano,Roberto Di Lauro,Mariastella Zannini,Mariastella Zannini +4 more
TL;DR: This study demonstrates that the reintroduction of Pax8 in PCPy cells is sufficient to activate expression of the endogenous genes encoding thyroglobulin, thyroperoxidase, and sodium/iodide symporter, and suggests a fundamental role of this transcription factor in the maintenance of functional differentiation in thyroid cells.