R
R Di Lauro
Researcher at University of Naples Federico II
Publications - 33
Citations - 5395
R Di Lauro is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Thyroglobulin & Thyroid. The author has an hindex of 27, co-authored 33 publications receiving 5273 citations. Previous affiliations of R Di Lauro include European Bioinformatics Institute.
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Journal ArticleDOI
The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain.
TL;DR: The early detection of TTF-1 in the endodermal cells of the thyroid and lung anlage and in restricted neuroblast populations indicates that T TF-1 may have a role in cell determination in these three systems and that additional mechanisms may be involved in the activation of thyroid-specific gene expression.
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Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity.
TL;DR: The cDNA for TTF‐1, a thyroid nuclear factor that binds to the promoter of thyroid specific genes, has been cloned and the protein encoded by the cDNA shows binding properties indistinguishable from those of TTF•1 present in nuclear extracts of differentiated rat thyroid cells.
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A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter.
TL;DR: The results suggest that the tissue‐specific expression of the thyroglobulin genes is mediated, at least in part, by the presence of a transcription factor exclusively in thyroid cells.
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Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain
M. Price,D. Lazzaro,T.M. Pohl,Marie-Geneviève Mattei,U. Ruther,J. C. Olivo,Denis Duboule,R Di Lauro +7 more
TL;DR: A novel mouse homeobox-containing gene, Nkx-2.2, which is a member of a family of genes whose homeodomains are homologous to that of the Drosophila NK-2 gene, may be involved in specifying diencephalic neuromeric boundaries.
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Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters.
TL;DR: The Pax-8 protein binds, through its paired domain, to the promoters of thyroglobulin and thyroperoxidase, genes that are exclusively expressed in the thyroid, representing the first identified natural targets for transcriptional activation by a paired domain-containing protein.