Marie-Anne Raquin

TL;DR: This preliminary study further supports the rationale for de-escalation of CSI doses and volumes in standard-risk PF tumors and shows a significant correlation between the full-scale IQ score and the CSI dose.

TL;DR: Conventional chemotherapy alone can be used to cure children with non-metastatic medulloblastoma who have gross total resection confirmed by early radiological assessment, but is not sufficient for treatment of those with metastatic or incompletely resected medullOBlastoma.

TL;DR: A significant proportion of children with ependymoma can avoid radiotherapy with prolonged adjuvant chemotherapy, and deferring irradiation at the time of relapse did not compromise overall survival of the entire patient population.

TL;DR: Data confirm and extend previous observations that CTNNB1‐mutated tumours represent a distinct molecular subgroup of medulloblastomas with favourable outcome, indicating that therapy de‐escalation should be considered.

TL;DR: Both epipodophyllotoxins and anthracyclines increase the risk of secondary leukemia, and the current challenge is to minimize the mutagenic effects of these drugs by diminishing cumulative doses without losing the therapeutic benefits.