S
Stéphanie Puget
Researcher at Necker-Enfants Malades Hospital
Publications - 203
Citations - 9530
Stéphanie Puget is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Medulloblastoma & Medicine. The author has an hindex of 42, co-authored 182 publications receiving 7301 citations. Previous affiliations of Stéphanie Puget include University of Paris-Sud & Boston Children's Hospital.
Papers
More filters
Journal ArticleDOI
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Dominik Sturm,Dominik Sturm,Brent A. Orr,Umut H. Toprak,Volker Hovestadt,David T.W. Jones,David Capper,David Capper,Martin Sill,Ivo Buchhalter,Paul A. Northcott,Irina Leis,Marina Ryzhova,Christian Koelsche,Christian Koelsche,Elke Pfaff,Elke Pfaff,Sariah Allen,Gnanaprakash Balasubramanian,Barbara C. Worst,Barbara C. Worst,Kristian W. Pajtler,Sebastian Brabetz,Pascal Johann,Pascal Johann,Felix Sahm,Felix Sahm,Jüri Reimand,Jüri Reimand,Alan Mackay,Diana Carvalho,Marc Remke,Joanna J. Phillips,Arie Perry,Cynthia Cowdrey,Rachid Drissi,Maryam Fouladi,Felice Giangaspero,Maria Łastowska,Wiesława Grajkowska,Wolfram Scheurlen,Torsten Pietsch,Christian Hagel,Johannes Gojo,Daniela Lötsch,Walter Berger,Irene Slavc,Christine Haberler,Anne Jouvet,Stefan Holm,Silvia Hofer,Marco Prinz,Catherine Keohane,Iris Fried,Christian Mawrin,David Scheie,Bret C. Mobley,Matthew Schniederjan,Mariarita Santi,Anna Maria Buccoliero,Sonika Dahiya,Christof M. Kramm,André O. von Bueren,Katja von Hoff,Stefan Rutkowski,Christel Herold-Mende,Michael C. Frühwald,Till Milde,Till Milde,Martin Hasselblatt,Pieter Wesseling,Pieter Wesseling,Jochen Rößler,Ulrich Schüller,Martin Ebinger,Jens Schittenhelm,Stephan Frank,Rainer Grobholz,Istvan Vajtai,Volkmar Hans,Reinhard Schneppenheim,Karel Zitterbart,V. Peter Collins,Eleonora Aronica,Pascale Varlet,Stéphanie Puget,Christelle Dufour,Jacques Grill,Dominique Figarella-Branger,Marietta Wolter,Martin U. Schuhmann,Tarek Shalaby,Michael A. Grotzer,Timothy E. Van Meter,Camelia M. Monoranu,Jörg Felsberg,Guido Reifenberger,Matija Snuderl,Lynn Ann Forrester,Jan Koster,Rogier Versteeg,Richard Volckmann,Peter van Sluis,Stephan Wolf,Tom Mikkelsen,Amar Gajjar,Kenneth Aldape,Andrew S. Moore,Michael D. Taylor,Chris Jones,Nada Jabado,Matthias A. Karajannis,Roland Eils,Matthias Schlesner,Peter Lichter,Andreas von Deimling,Andreas von Deimling,Stefan M. Pfister,Stefan M. Pfister,David W. Ellison,Andrey Korshunov,Andrey Korshunov,Marcel Kool +122 more
TL;DR: It is demonstrated that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors.
Journal ArticleDOI
Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
Sebastian Bender,Sebastian Bender,Yujie Tang,Anders Lindroth,Volker Hovestadt,David T.W. Jones,Marcel Kool,Marc Zapatka,Paul A. Northcott,Dominik Sturm,Wei Wang,Bernhard Radlwimmer,Jonas W. Højfeldt,Nathalene Truffaux,David Castel,Simone Schubert,Marina Ryzhova,Huriye Seker-Cin,Jan Gronych,Pascal-David Johann,Pascal-David Johann,Sebastian Stark,Sebastian Stark,Jochen Meyer,Jochen Meyer,Till Milde,Till Milde,Martin U. Schuhmann,Martin Ebinger,Camelia M. Monoranu,Anitha Ponnuswami,S. Chen,Chris Jones,Olaf Witt,Olaf Witt,V. Peter Collins,Andreas von Deimling,Andreas von Deimling,Nada Jabado,Stéphanie Puget,Jacques Grill,Kristian Helin,Andrey Korshunov,Andrey Korshunov,Peter Lichter,Michelle Monje,Christoph Plass,Yoon Jae Cho,Stefan M. Pfister,Stefan M. Pfister +49 more
TL;DR: It is shown that reduced H3K27me3 levels and DNA hypomethylation act in concert to activate gene expression in K27M mutant pHGGs, and it is demonstrated that this is caused by aberrant recruitment of the PRC2 complex to K 27M mutant H3.3.
Journal ArticleDOI
Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.
David Castel,Cathy Philippe,Raphael Calmon,Ludivine Le Dret,Nathalene Truffaux,Nathalie Boddaert,Mélanie Pagès,Kathryn R. Taylor,Patrick Saulnier,Ludovic Lacroix,Alan Mackay,Chris Jones,Christian Sainte-Rose,Thomas Blauwblomme,Felipe Andreiuolo,Stéphanie Puget,Jacques Grill,Pascale Varlet,Marie-Anne Debily,Marie-Anne Debily +19 more
TL;DR: H3K27 alterations appear as the founding event in DIPG and the mutations in the two main histone H3 variants drive two distinct oncogenic programmes with potential specific therapeutic targets.
Journal ArticleDOI
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
Kathryn R. Taylor,Alan Mackay,Nathalene Truffaux,Yaron S. Butterfield,Olena Morozova,Olena Morozova,Cathy Philippe,David Castel,Catherine S. Grasso,Maria Vinci,Diana Carvalho,Angel M. Carcaboso,Carmen de Torres,Ofelia Cruz,Jaume Mora,Natacha Entz-Werle,Wendy J. Ingram,Michelle Monje,Darren Hargrave,Alex N. Bullock,Stéphanie Puget,Stephen Yip,Chris Jones,Jacques Grill +23 more
TL;DR: The identification of recurrent activating mutations in the ACVR1 gene, which encodes a type I activin receptor serine/threonine kinase, in 21% of DIPG samples are reported, which represent new targets for therapeutic intervention in this otherwise incurable disease.
Journal ArticleDOI
Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement.
Stéphanie Puget,Matthew R. Garnett,Alison Wray,Jacques Grill,Jean-Louis Habrand,Nathalie Bodaert,Michel Zerah,Mercia Bezerra,Dominique Renier,Alain Pierre-Kahn,Christian Sainte-Rose +10 more
TL;DR: By using a preoperative classification system to grade hypothalamic involvement and stratify treatment, the authors were able to minimize devastating morbidity in patients with craniopharyngiomas.