M
Marie-Françoise Simon
Researcher at French Institute of Health and Medical Research
Publications - 37
Citations - 2207
Marie-Françoise Simon is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Lysophosphatidic acid & Phospholipase A2. The author has an hindex of 22, co-authored 37 publications receiving 2154 citations. Previous affiliations of Marie-Françoise Simon include Paul Sabatier University.
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Journal ArticleDOI
Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells
Olivier Fourcade,Marie-Françoise Simon,Cécile Viodé,Nathalie Rugani,François Leballe,Ashraf Ragab,Bernard Fournié,Louis Sarda,Hugues Chap +8 more
TL;DR: It is concluded that upon loss of phospholipid asymmetry, cell-derived microvesicles provide a preferential substrate for sPLA2, and the novel lipid mediator LPA can be generated by this pathway.
Journal ArticleDOI
Lysophosphatidic acid synthesis and release.
TL;DR: The different physio-pathological situations associated with LPA production, as well as the potential role played by LPA in genesis of certain diseases (cancer, obesity, arteriosclerosis) are listed and analyzed.
Journal ArticleDOI
Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis
Frédérique Gaits,Olivier Fourcade,François Le Balle,Geneviève Gueguen,Bernadette Gaigé,Ama Gassama-Diagne,Josette Fauvel,Jean-Pierre Salles,Gérard Mauco,Marie-Françoise Simon,Hugues Chap +10 more
TL;DR: A survey of literature data indicates some interesting issues which might be used as the basis for further molecular characterization of phospholipases A able to degrade phosphatidic acid.
Journal ArticleDOI
Phosphatidic and lysophosphatidic acid production in phospholipase C-and thrombin-treated platelets. Possible involvement of a platelet lipase.
TL;DR: A mechanism for phosph atidic and lysophosphatidic acid production is proposed, involving a phosphorylation of the di- and monoglycerides formed upon phospholipase C and lipase action, and the possible role of such a pathway in regulating arachidonic acid release from phospholIPids during platelet activation is discussed.
Journal ArticleDOI
Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis.
Kees Jalink,Trudi Hengeveld,S Mulder,Friso R. Postma,Marie-Françoise Simon,Hugues Chap,G. A. Van Der Marel,J. H. Van Boom,W J van Blitterswijk,Wouter H. Moolenaar +9 more
TL;DR: The results indicate that, although many features of the LPA structure are important for optimal activity, the phosphate group is most critical, suggesting that this moiety is directly involved in receptor activation.