Marie-Thérèse Nugeyre

TL;DR: Comparison of the vaginal cynomolgus macaque microbiota with that of humans showed similarity to community state type IV-A usually associated with dysbiosis, and the relative abundance of 12 bacterial genera was found to be associated with progesterone levels.

TL;DR: The microenvironment generated by TEC-thymocyte interaction might greatly favor optimal HIV-1 replication in the thymus, and the synergistic effects of tumor necrosis factor, interleukin-1 (IL-1), IL-6, and granulocyte-macrophage colony-stimulating factor may account by themselves for the high level of HIV- 1 replication in thymocytes observed in mixed cultures.

TL;DR: It is found that activation of Toll-like receptors 7 and 8 expressed by dM reinforces the low permissivity of dM to HIV-1 by restricting viral replication and inducing secretion of cytokines in the decidual environment, including IFN-γ, that shape dM plasticity.

TL;DR: The cytokine profile induced by TLR activation in the FRT supports the role of these tissues in genital anti-microbial immunity and in the control of inflammation while allowing maintenance of its reproductive function.

TL;DR: The findings indicate that the low T-cell colony formation in some AIDS patients could be due to adherent cell-derived inhibitory activity(ies), which could be abrogated by heating or treatment with proteolytic enzymes.