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Nicolas Tchitchek
Researcher at University of Paris
Publications - 78
Citations - 1808
Nicolas Tchitchek is an academic researcher from University of Paris. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 20, co-authored 69 publications receiving 1333 citations. Previous affiliations of Nicolas Tchitchek include Centre national de la recherche scientifique & University of Paris-Sud.
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The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea
Kathrin Endt,Baerbel Stecher,Samuel Chaffron,Emma Slack,Nicolas Tchitchek,Arndt Benecke,Laurye Van Maele,Jean-Claude Sirard,Andreas J. Mueller,Mathias Heikenwalder,Andrew J. Macpherson,Richard A. Strugnell,Christian von Mering,Wolf-Dietrich Hardt +13 more
TL;DR: The microbiota confers colonization resistance and mediates pathogen clearance in primary infections, while sIgA protects from disease if the host re-encounters the same pathogen, which has implications for curing S. typhimurium diarrhea and for preventing transmission.
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Progenitors from the central nervous system drive neurogenesis in cancer
Philippe Mauffrey,Nicolas Tchitchek,Vilma Barroca,Alexis-Pierre Bemelmans,Virginie Firlej,Yves Allory,Paul-Henri Romeo,Claire Magnon +7 more
TL;DR: It is shown that neural progenitors from the central nervous system that express doublecortin (DCX+) infiltrate prostate tumours and metastases, in which they initiate neurogenesis, and can generate new adrenergic neurons in tumour, and indicate neural targets for the treatment of cancer.
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Annotation of long non-coding RNAs expressed in Collaborative Cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts
Laurence Josset,Nicolas Tchitchek,Lisa E. Gralinski,Martin T. Ferris,Amie J. Eisfeld,Richard Green,Matthew J. Thomas,Jennifer Tisoncik-Go,Gary P. Schroth,Yoshihiro Kawaoka,Fernando Pardo-Manuel de Villena,Ralph S. Baric,Mark T. Heise,Xinxia Peng,Michael G. Katze +14 more
TL;DR: A broad categorization of potential lncRNA functions is provided and subsets of lncRNAs with likely key roles in respiratory virus pathogenesis are identified.
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A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses.
Hugh D. Mitchell,Amie J. Eisfeld,Amy C. Sims,Jason E. McDermott,Melissa M. Matzke,Bobbi Jo M. Webb-Robertson,Susan C. Tilton,Nicolas Tchitchek,Laurence Josset,Chengjun Li,Amy L. Ellis,Jean H. Chang,Robert A. Heegel,Maria L. Luna,Athena A. Schepmoes,Anil K. Shukla,Thomas O. Metz,Gabriele Neumann,Arndt Benecke,Arndt Benecke,Richard D. Smith,Ralph S. Baric,Yoshihiro Kawaoka,Michael G. Katze,Katrina M. Waters +24 more
TL;DR: An integrated network interrogation approach is implemented, in which proteome and transcriptome datasets from infection of both viruses in human lung epithelial cells are utilized to predict regulatory genes involved in the host response.
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Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus
Pierre Roques,Karl Ljungberg,Beate M. Kümmerer,Leslie Gosse,Nathalie Dereuddre-Bosquet,Nicolas Tchitchek,David Hallengärd,Juan García-Arriaza,Andreas Meinke,Mariano Esteban,Andres Merits,Roger Le Grand,Peter Liljeström +12 more
TL;DR: These vaccines are based on an East/Central/South African strain of Indian Ocean lineage, but they also generated neutralizing antibodies against an isolate of the Asian genotype that now is rapidly spreading across the Americas.