R
Roger Le Grand
Researcher at Université Paris-Saclay
Publications - 44
Citations - 1597
Roger Le Grand is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Vaccination & Immune system. The author has an hindex of 9, co-authored 44 publications receiving 730 citations. Previous affiliations of Roger Le Grand include University of Paris-Sud & French Institute of Health and Medical Research.
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Journal ArticleDOI
Animal models for COVID-19.
César Muñoz-Fontela,William E. Dowling,Simon G. P. Funnell,Pierre Stéphane Gsell,A. Ximena Riveros-Balta,Randy A. Albrecht,Hanne Leth Andersen,Ralph S. Baric,Miles W. Carroll,Marco Cavaleri,Chuan Qin,Ian Crozier,Kai Dallmeier,Leon de Waal,Emmie de Wit,Leen Delang,Erik D. Dohm,W. Paul Duprex,Darryl Falzarano,Courtney L. Finch,Matthew B. Frieman,Barney S. Graham,Lisa E. Gralinski,Kate Guilfoyle,Bart L. Haagmans,Geraldine A. Hamilton,Amy L. Hartman,Sander Herfst,Suzanne J.F. Kaptein,William B. Klimstra,Ivana Knezevic,Philip R. Krause,Jens H. Kuhn,Roger Le Grand,Mark G. Lewis,Wen-Chun Liu,Pauline Maisonnasse,Anita K. McElroy,Vincent J. Munster,Nadia Oreshkova,Angela L. Rasmussen,Joana Rocha-Pereira,Barry Rockx,Estefanía Rodríguez,Thomas F. Rogers,Francisco J. Salguero,Michael Schotsaert,Koert J. Stittelaar,Hendrik Jan Thibaut,Chien Te K. Tseng,Júlia Vergara-Alert,Martin Beer,Trevor Brasel,Jasper Fuk-Woo Chan,Adolfo García-Sastre,Johan Neyts,Stanley Perlman,Douglas S. Reed,Juergen A. Richt,Chad J. Roy,Joaquim Segalés,Seshadri S. Vasan,Seshadri S. Vasan,Ana Maria Henao-Restrepo,Dan H. Barouch +64 more
TL;DR: The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.
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Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates.
Pauline Maisonnasse,Jeremie Guedj,Vanessa Contreras,Sylvie Behillil,Sylvie Behillil,Caroline Solas,Romain Marlin,Thibaut Naninck,Andrés Pizzorno,Julien Lemaitre,Antonio Gonçalves,Nidhal Kahlaoui,Olivier Terrier,Raphael Ho Tsong Fang,Vincent Enouf,Vincent Enouf,Nathalie Dereuddre-Bosquet,Angela Brisebarre,Angela Brisebarre,Franck Touret,Catherine Chapon,Bruno Hoen,Bruno Lina,Manuel Rosa Calatrava,Sylvie van der Werf,Sylvie van der Werf,Xavier de Lamballerie,Roger Le Grand +27 more
TL;DR: Hydroxychloroquine did not confer protection against SARS-CoV-2 infection or reduce the viral load after infection in macaques; these findings do not support the use of hydroxy chloroquine as an antiviral drug treatment of COVID-19 in humans.
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Specific Biological Features of Adipose Tissue, and Their Impact on HIV Persistence.
Christine Bourgeois,Jennifer Gorwood,Aurélie Barrail-Tran,Claire Lagathu,Jacqueline Capeau,Delphine Desjardins,Roger Le Grand,Abderaouf Damouche,Véronique Béréziat,Olivier Lambotte +9 more
TL;DR: AT’s intrinsic metabolic features, large overall mass, and wide distribution make it a major tissue reservoir, and one that may contribute to the pathophysiology of chronic HIV infections, and the respective impacts of both intrinsic and HIV-induced factors on AT’'s involvement as a viral reservoir are evaluated.
Journal ArticleDOI
SARS-CoV-2 infection in nonhuman primates alters the composition and functional activity of the gut microbiota.
Harry Sokol,Harry Sokol,Vanessa Contreras,Pauline Maisonnasse,Aurore Desmons,Benoit Delache,Valentin Sencio,Arnaud Machelart,Angela Brisebarre,Lydie Humbert,Lucie Deryuter,Emilie Gauliard,Séverine Heumel,Dominique Rainteau,Nathalie Dereuddre-Bosquet,Elisabeth Menu,Raphael Ho Tsong Fang,Antonin Lamaziere,Antonin Lamaziere,Loic Brot,Loic Brot,Celine Wahl,Cyriane Oeuvray,Nathalie Rolhion,Sylvie van der Werf,Stéphanie Ferreira,Roger Le Grand,François Trottein +27 more
TL;DR: Analysis of the effects of a SARS-CoV-2 infection in a nonhuman primate model suggests changes in the gut microbiota’s composition and functional activity during a severe acute respiratory syndrome coronavirus 2 infection might be instrumental in understanding and controling COVID 19.
Journal ArticleDOI
Optimize Prime/Boost Vaccine Strategies: Trained Immunity as a New Player in the Game.
Jean-Louis Palgen,Jean-Louis Palgen,Yanis Feraoun,Gaëlle Dzangué-Tchoupou,Candie Joly,Frédéric Martinon,Roger Le Grand,Anne-Sophie Beignon +7 more
TL;DR: In this article, the authors discuss the potential of trained innate cells to be game-changers in prime/boost vaccine strategies and discuss how innate cells sense and respond differently to a 1st and a 2nd vaccine dose, both in an extrinsic and intrinsic manner.