M
Mariel Gindin
Researcher at Washington University in St. Louis
Publications - 1
Citations - 1983
Mariel Gindin is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 1, co-authored 1 publications receiving 1401 citations.
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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang,Jing Qiu,David O’Sullivan,Michael D. Buck,Takuro Noguchi,Jonathan D. Curtis,Qiongyu Chen,Mariel Gindin,Matthew M. Gubin,Gerritje J.W. van der Windt,Elena Tonc,Robert D. Schreiber,Edward J. Pearce,Erika L. Pearce +13 more
TL;DR: It is shown that tumor-imposed metabolic restrictions can mediate T cell hyporesponsiveness during cancer, and it is found that blocking PD-L1 directly on tumors dampens glycolysis by inhibiting mTOR activity and decreasing expression of gly colysis enzymes.