C
Chih-Hao Chang
Researcher at Washington University in St. Louis
Publications - 23
Citations - 9660
Chih-Hao Chang is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 14, co-authored 20 publications receiving 7429 citations. Previous affiliations of Chih-Hao Chang include University of Oxford & Trudeau Institute.
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Journal ArticleDOI
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang,Jing Qiu,David O’Sullivan,Michael D. Buck,Takuro Noguchi,Jonathan D. Curtis,Qiongyu Chen,Mariel Gindin,Matthew M. Gubin,Gerritje J.W. van der Windt,Elena Tonc,Robert D. Schreiber,Edward J. Pearce,Erika L. Pearce +13 more
TL;DR: It is shown that tumor-imposed metabolic restrictions can mediate T cell hyporesponsiveness during cancer, and it is found that blocking PD-L1 directly on tumors dampens glycolysis by inhibiting mTOR activity and decreasing expression of gly colysis enzymes.
Journal ArticleDOI
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chih-Hao Chang,Jonathan D. Curtis,Leonard B. Maggi,Brandon Faubert,Alejandro V. Villarino,David O’Sullivan,Stanley Ching-Cheng Huang,Gerritje J.W. van der Windt,Julianna Blagih,Jing Qiu,Jason D. Weber,Edward J. Pearce,Russell G. Jones,Erika L. Pearce +13 more
TL;DR: It is shown here that aerobic glycolysis is specifically required for effector function in T cells but that this pathway is not necessary for proliferation or survival.
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Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
Gerritje J.W. van der Windt,Bart Everts,Chih-Hao Chang,Jonathan D. Curtis,Tori C. Freitas,Eyal Amiel,Edward J. Pearce,Erika L. Pearce +7 more
TL;DR: It is shown that interleukin-15 (IL-15), a cytokine critical for CD8(+) memory T cells, regulated SRC and oxidative metabolism by promoting mitochondrial biogenesis and expression of carnitine palmitoyl transferase (CPT1a).
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Fueling immunity: insights into metabolism and lymphocyte function.
TL;DR: It is becoming increasingly clear that T cell function is intimately linked to metabolic programs, and as such there is a considerable and growing interest in developing techniques that target metabolism for immunotherapy.
Journal ArticleDOI
Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming
Michael D. Buck,Michael D. Buck,David O’Sullivan,Ramon I. Klein Geltink,Jonathan D. Curtis,Chih-Hao Chang,David E. Sanin,Jing Qiu,Jing Qiu,Oliver Kretz,Oliver Kretz,Daniel Braas,Gerritje J.W. van der Windt,Qiongyu Chen,Stanley Ching-Cheng Huang,Christina M. O’Neill,Brian T. Edelson,Edward J. Pearce,Edward J. Pearce,Hiromi Sesaki,Tobias B. Huber,Tobias B. Huber,Angelika S. Rambold,Angelika S. Rambold,Erika L. Pearce +24 more
TL;DR: The data suggest that, by altering cristae morphology, fusion in TM cells configures electron transport chain (ETC) complex associations favoring oxidative phosphorylation (OXPHOS) and FAO, while fission in TE cells leads to cristsae expansion, reducing ETC efficiency and promoting aerobic glycolysis.