Elena Tonc

TL;DR: It is shown that tumor-imposed metabolic restrictions can mediate T cell hyporesponsiveness during cancer, and it is found that blocking PD-L1 directly on tumors dampens glycolysis by inhibiting mTOR activity and decreasing expression of gly colysis enzymes.

TL;DR: It is shown that the transcription factor AP4 was required for sustained GC B cell proliferation and subsequent establishment of a diverse and protective antibody repertoire and B-cell-specific deletion of AP4 resulted in reduced GC sizes and reduced somatic hypermutation coupled with a failure to control chronic viral infection.

TL;DR: In this article, the T-bet-dependent TIM3-CX3CR1+ CD8 T cells contain a T-Bet-dependent PD-1 subpopulation that is distinct from the TIM3+CX 3 CR1+PD-1+ proliferative effector subset.

TL;DR: Subsets of PD-1+ CD8 T cells during chronic infection marked by expression of CX3CR1 with substantial in situ proliferation and high expression of granzyme B are defined, offering a prime target for novel immunotherapies.

TL;DR: In this paper , the authors synthesize epidemiological investigations, clinical biopsies and primary cell culture studies, and mechanistic insights from several pre-clinical models of vulvar pain.