M
Marija Vrljic
Researcher at Stanford University
Publications - 21
Citations - 2029
Marija Vrljic is an academic researcher from Stanford University. The author has contributed to research in topics: Synaptotagmin 1 & Synaptotagmin I. The author has an hindex of 17, co-authored 21 publications receiving 1927 citations. Previous affiliations of Marija Vrljic include Howard Hughes Medical Institute.
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Journal ArticleDOI
Liquid-Liquid Immiscibility in Membranes
TL;DR: The properties of defined cholesterol-phospholipid mixtures provide a conceptual foundation for the exploration of a number of aspects of the biophysics and biochemistry of animal cell membranes.
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Translational diffusion of individual class II MHC membrane proteins in cells.
TL;DR: This study finds no strong evidence for significant confinement of either GPI-linked or native I-E(k) in the plasma membrane of CHO cells, and analyses show that motion is predominantly Brownian.
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Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex.
TL;DR: An experimentally determined model of the elusive Syt1–SNARE complex is obtained using a multibody docking approach with 34 FRET-derived distances as restraints, suggesting a common mechanism by which the interaction between synaptotagmins and SNAREs aids in Ca2+-triggered fusion.
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Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion.
Jiajie Diao,Patricia Grob,Patricia Grob,Daniel J. Cipriano,Daniel J. Cipriano,Minjoung Kyoung,Minjoung Kyoung,Yunxiang Zhang,Yunxiang Zhang,Sachi Shah,Sachi Shah,Amie Nguyen,Amie Nguyen,Mark S. Padolina,Mark S. Padolina,Ankita Srivastava,Ankita Srivastava,Marija Vrljic,Marija Vrljic,Ankita Shah,Ankita Shah,Eva Nogales,Eva Nogales,Eva Nogales,Steven Chu,Steven Chu,Axel T. Brunger,Axel T. Brunger +27 more
TL;DR: A single vesicle–vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes is used to decipher the temporal sequence of membrane states upon Ca2+-injection at 250–500 μM on a 100-ms timescale and discovers a heterogeneous network of immediate and delayed fusion pathways.
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In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release
Minjoung Kyoung,Ankita Srivastava,Yunxiang Zhang,Jiajie Diao,Marija Vrljic,Patricia Grob,Eva Nogales,Steven Chu,Axel T. Brunger +8 more
TL;DR: An in vitro system with reconstituted synaptic proteins that meets the long-sought goal to produce fast content release in the millisecond time regime upon Ca2+ triggering and shows that the combination of SNAREs with synaptotagmin lowers the activation barriers to full fusion, and that complexin enhances this kinetic control.