M
Marika Kiessling
Researcher at Heidelberg University
Publications - 55
Citations - 3525
Marika Kiessling is an academic researcher from Heidelberg University. The author has contributed to research in topics: Immediate early gene & Glutamate receptor. The author has an hindex of 30, co-authored 54 publications receiving 3429 citations.
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Journal ArticleDOI
Intravenous Brain-Derived Neurotrophic Factor Reduces Infarct Size and Counterregulates Bax and Bcl-2 Expression After Temporary Focal Cerebral Ischemia
Wolf-R. Schäbitz,Clemens Sommer,Werner Zoder,Marika Kiessling,Markus Schwaninger,Stefan Schwab +5 more
TL;DR: One possible mechanism of action of neuroprotection of BDNF after focal ischemia appears to be counterregulation of Bax/Bcl-2 proteins within the ischemic penumbra within animals treated with intravenous BDNF.
Journal ArticleDOI
Effect of Brain-Derived Neurotrophic Factor Treatment and Forced Arm Use on Functional Motor Recovery After Small Cortical Ischemia
W.R. Schäbitz,Christian Berger,Rainer Kollmar,M. Seitz,E. Tanay,Marika Kiessling,Stefan Schwab,Clemens Sommer +7 more
TL;DR: Postischemic intravenous BDNF treatment improves functional motor recovery after photothrombotic stroke and induces widespread neuronal remodeling.
Journal ArticleDOI
Amplification of the epidermal-growth-factor-receptor gene correlates with different growth behaviour in human glioblastoma.
Jürgen Schlegel,Annette Merdes,Gabi Stumm,F. K. Albert,Michael Forsting,Nancy E. Hynes,Marika Kiessling +6 more
TL;DR: There was a statistically significant difference in the mean latency period until tumour regrowth of patients suffering from GBM with and without EGF‐receptor‐gene amplification (9 weeks vs 32 weeks).
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Antitumor Vaccination of Patients With Glioblastoma Multiforme: A Pilot Study to Assess Feasibility, Safety, and Clinical Benefit
Hans H. Steiner,Matteo M. Bonsanto,Philipp Beckhove,Michael Brysch,Karsten Geletneky,Rezvan Ahmadi,Rebecca Schuele-Freyer,P. Kremer,Golamreza Ranaie,Dejana Matejic,Harald Bauer,Marika Kiessling,Stefan Kunze,Volker Schirrmacher,Christel Herold-Mende +14 more
TL;DR: Postoperative vaccination with virus-modified autologous tumor cells seems to be feasible and safe and to improve the prognosis of patients with glioblastomas, substantiated by the observed antitumor immune response.
Journal ArticleDOI
JUN, FOS, KROX, and CREB transcription factor proteins in the rat cortex: basal expression and induction by spreading depression and epileptic seizures.
Thomas Herdegen,Jürgen Sandkühler,Peter Gass,Marika Kiessling,Rodrigo Bravo,Manfred Zimmermann +5 more
TL;DR: Topical KCl induced cortical spreading depression and systemic injection of bicuculline evoked generalized tonic‐clonic seizures, and expression patterns were studied in untreated rats.