M
Marika Markkanen
Researcher at University of Helsinki
Publications - 11
Citations - 460
Marika Markkanen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Gene isoform & Cotransporter. The author has an hindex of 8, co-authored 11 publications receiving 394 citations.
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Journal ArticleDOI
A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2.
Pavel Uvarov,Anastasia Ludwig,Marika Markkanen,Priit Pruunsild,Kai Kaila,Eric Delpire,Tõnis Timmusk,Claudio Rivera,Matti S. Airaksinen +8 more
TL;DR: Different populations of neurons show a differential dependence on the expression of the two isoforms: KCC2a expression in the absence of K CC2b is presumably sufficient to support vital neuronal functions in the brain stem and spinal cord but not in the cortex.
Journal ArticleDOI
Coexpression and Heteromerization of Two Neuronal K-Cl Cotransporter Isoforms in Neonatal Brain
Pavel Uvarov,Anastasia Ludwig,Marika Markkanen,Shetal Soni,Christian A. Hübner,Claudio Rivera,Matti S. Airaksinen +6 more
TL;DR: An antibody against the KCC2a isoform is characterized and it is shown that a previously described antibody against KCC1 is specific for the K CC2b isoform, suggesting the presence of endogenous KCC 2a-KCC2b heteromers.
Journal ArticleDOI
Upregulation of the Neuron-Specific K+/Cl− Cotransporter Expression by Transcription Factor Early Growth Response 4
TL;DR: The results indicate an important role for Egr4 in the developmental upregulation of KCC2 gene expression, which shows a similar developmental up regulation in CNS neurons as K CC2.
Journal ArticleDOI
Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS.
Marika Markkanen,Tuula Karhunen,Olaya Llano,Anastasia Ludwig,Claudio Rivera,Pavel Uvarov,Matti S. Airaksinen +6 more
TL;DR: KCC2a and KCC2b have overlapping roles in neonatal neurons but presumably different roles in mature neurons, as suggested in previous studies.
Journal ArticleDOI
Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K-Cl cotransporter KCC2.
TL;DR: The results suggest that binding of USF proteins to the E-boxKCC2b may contribute to the upregulation of K CC2b gene expression in developing brain.