P
Priit Pruunsild
Researcher at Tallinn University of Technology
Publications - 22
Citations - 2158
Priit Pruunsild is an academic researcher from Tallinn University of Technology. The author has contributed to research in topics: Transcription factor & Brain-derived neurotrophic factor. The author has an hindex of 17, co-authored 20 publications receiving 1950 citations. Previous affiliations of Priit Pruunsild include National Institute of Chemical Physics and Biophysics.
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Journal ArticleDOI
Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters
TL;DR: It is shown that BDNF and antiBD NF transcripts form dsRNA duplexes in the brain in vivo, suggesting an important role for antiBDNF in regulating BDNF expression in human.
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LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia
Clyde Francks,Shinji Maegawa,Juha Lauren,Brett S. Abrahams,Antonio Velayos-Baeza,Sarah E. Medland,Sarah E. Medland,Stefano Colella,Matthias Groszer,E. Z. McAuley,Tara M. Caffrey,Tõnis Timmusk,Priit Pruunsild,Indrek Koppel,Penelope A. Lind,N. Matsumoto-Itaba,Jérôme Nicod,Lan Xiong,Ridha Joober,Wolfgang Enard,B. Krinsky,Eiji Nanba,Anthony J. Richardson,Brien P. Riley,Nicholas G. Martin,Stephen M. Strittmatter,H.-J. Möller,Dan Rujescu,D. St Clair,Pierandrea Muglia,J. L. Roos,Simon E. Fisher,Richard Wade-Martins,Guy A. Rouleau,John F. Stein,Maria Karayiorgou,Daniel H. Geschwind,Jiannis Ragoussis,K. S. Kendler,Matti S. Airaksinen,Mitsuo Oshimura,Lynn E. DeLisi,Anthony P. Monaco +42 more
TL;DR: It is shown that LRRTM1 is expressed during the development of specific forebrain structures, and thus could influence neuronal differentiation and connectivity, and the first putative genetic effect on variability in human brain asymmetry is found.
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Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene.
TL;DR: The results of this study have identified the cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene and demonstrated that CRE and PasRE elements in hBDNF promoter IX are required for the induction of this promoter by neuronal activity.
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A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2.
Pavel Uvarov,Anastasia Ludwig,Marika Markkanen,Priit Pruunsild,Kai Kaila,Eric Delpire,Tõnis Timmusk,Claudio Rivera,Matti S. Airaksinen +8 more
TL;DR: Different populations of neurons show a differential dependence on the expression of the two isoforms: KCC2a expression in the absence of K CC2b is presumably sufficient to support vital neuronal functions in the brain stem and spinal cord but not in the cortex.
Journal ArticleDOI
Long-lasting behavioural and molecular alterations induced by early postnatal fluoxetine exposure are restored by chronic fluoxetine treatment in adult mice
TL;DR: It is shown that early-life fluoxetine exposure resulted in the long-term upregulation of BDNF expression in adult mice, however, chromatin immunoprecipitation studies did not reveal any changes in the acetylation or trimethylation of histone H3 at the BDNF promoters.