J
Jade K. Forwood
Researcher at Charles Sturt University
Publications - 149
Citations - 3590
Jade K. Forwood is an academic researcher from Charles Sturt University. The author has contributed to research in topics: Importin & Nuclear localization sequence. The author has an hindex of 28, co-authored 127 publications receiving 3017 citations. Previous affiliations of Jade K. Forwood include Monash University, Clayton campus & James Cook University.
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Journal ArticleDOI
Molecular basis for specificity of nuclear import and prediction of nuclear localization
Mary Marfori,Andrew V. Mynott,Jonathan Ellis,Ahmed M. Mehdi,Neil F. W. Saunders,Paul M. G. Curmi,Jade K. Forwood,Mikael Bodén,Bostjan Kobe,Bostjan Kobe +9 more
TL;DR: In this paper, the authors review the current understanding of the molecular determinants of the specificity of nuclear import, focusing on the importin-α•cargo recognition, as well as the currently available databases and predictive tools relevant to nuclear localization.
Journal ArticleDOI
Structural Biology and Regulation of Protein Import into the Nucleus
Mary Christie,Chiung-Wen Chang,Chiung-Wen Chang,Gergely Róna,Kate Smith,Alastair G. Stewart,Agnes A.S. Takeda,Marcos R.M. Fontes,Murray Stewart,Beáta G. Vértessy,Jade K. Forwood,Bostjan Kobe +11 more
TL;DR: The structural basis of the principal nuclear import pathways and the molecular basis of their regulation are reviewed and post-translational modifications, particularly phosphorylation, constitute key regulatory mechanisms operating in these pathways.
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Crystal structures of flax rust avirulence proteins AvrL567-A and -D reveal details of the structural basis for flax disease resistance specificity
Ching-I Anderson Wang,Gregor Gunčar,Jade K. Forwood,Trazel Teh,Ann-Maree Catanzariti,Gregory J. Lawrence,Fionna E. Loughlin,Joel P. Mackay,Horst Joachim Schirra,Peter A. Anderson,Jeffrey G. Ellis,Peter N. Dodds,Bostjan Kobe +12 more
TL;DR: These studies provide some of the first structural information on avirulence proteins that bind directly to the corresponding resistance proteins, allowing an examination of the molecular basis of the interaction with the resistance proteins as a step toward designing new resistance specificities.
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Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations.
Vincent R. Harley,Sharon Layfield,Claire L. Mitchell,Jade K. Forwood,Anna P. John,Lyndall J. Briggs,Sharon G. McDowall,David A. Jans +7 more
TL;DR: It is concluded that SRY normally requires the two distinct NLS-dependent nuclear import pathways to reach sufficient levels in the nucleus for sex determination, and cases of human disease being explained, at a molecular level, by the impaired ability of a protein to accumulate inThe nucleus.
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Functional and structural properties of mammalian acyl-coenzyme A thioesterases
TL;DR: The current knowledge on the structure, function and regulation of this enzyme family is summarized.