M
Marino Artico
Researcher at Sapienza University of Rome
Publications - 125
Citations - 3648
Marino Artico is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Aryl & Pyrrole. The author has an hindex of 33, co-authored 125 publications receiving 3465 citations. Previous affiliations of Marino Artico include University of Salerno & University of Siena.
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Journal ArticleDOI
New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure−Activity Relationships and Molecular Modeling Studies
Gabriella De Martino,Michael C. Edler,Giuseppe La Regina,Antonio Coluccia,Maria Chiara Barbera,Denise Barrow,Robert Ian Nicholson,Gabriela Chiosis,Andrea Brancale,Ernest Hamel,Marino Artico,Romano Silvestri +11 more
TL;DR: From careful analysis of the biological and in silico data, the authors can hypothesize a basic pharmacophore for this class of compounds and show that Dynamics simulation studies correlate well with the observed experimental data.
Journal ArticleDOI
Arylthioindoles, Potent Inhibitors of Tubulin Polymerization
Gabriella De Martino,Giuseppe La Regina,Antonio Coluccia,Michael C. Edler,Maria Chiara Barbera,Andrea Brancale,Elizabeth Wilcox,Ernest Hamel,Marino Artico,Romano Silvestri +9 more
TL;DR: Several arylthioindoles had excellent activity as inhibitors both of tubulin polymerization and of the growth of MCF-7 human breast carcinoma cells.
Journal ArticleDOI
Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies
Giuseppe La Regina,Michael C. Edler,Andrea Brancale,Sahar Kandil,Antonio Coluccia,Francesco Piscitelli,Ernest Hamel,Gabriella De Martino,Ruth Matesanz,José Fernando Díaz,Anna Ivana Scovassi,Ennio Prosperi,Antonio Lavecchia,Ettore Novellino,Marino Artico,Romano Silvestri +15 more
TL;DR: Molecular modeling studies showed that, despite the absence of the ester moiety present in the previously examined analogues, most of the compounds bind in the colchicine site in the same orientation as the previously studied ATIs.
Journal ArticleDOI
Novel Indolyl Aryl Sulfones Active against HIV-1 Carrying NNRTI Resistance Mutations: Synthesis and SAR Studies
Romano Silvestri,Gabriella De Martino,Giuseppe La Regina,Marino Artico,Silvio Massa,Laura Vargiu,Massimo Mura,Anna Giulia Loi,Tiziana Marceddu,Paolo La Colla +9 more
TL;DR: Introduction of two methyl groups at positions 3 and 5 of the phenyl ring of 2 furnished derivatives showed very potent and selective anti-HIV-1 activity not only against the wt strain, but also against mutants carrying NNRTI-resistant mutations at positions 103 and 181 of the reverse transcriptase gene.
Journal ArticleDOI
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.
Rino Ragno,Antonio Coluccia,Giuseppe La Regina,Gabriella De Martino,Francesco Piscitelli,Antonio Lavecchia,Ettore Novellino,Alberto Bergamini,Chiara Ciaprini,Anna Sinistro,Giovanni Maga,Emanuele Crespan,Marino Artico,Romano Silvestri +13 more
TL;DR: These compounds, and in particular compound 9, also showed excellent inhibitory activity against both HIV-112 and HIV-AB1 primary isolates in lymphocytes and against HIV WT in macrophages.