Mario L. Suvà

TL;DR: Novel glioblastoma organoid models and single-cell RNA-sequencing technologies are leveraged to tackle the tumor's heterogeneous nature, providing new tools and insights into tumor biology.

TL;DR: A team led by Priscilla Brastianos and Tracy Batchelor analyzed the genetic landscape of glioblastoma by comparing pre-treatment and autopsy tumor specimens from 12 patients who died of the aggressive brain cancer and identified a common set of four genetic events that occurred early in the evolution of nearly every patient’s cancer: three losses or gains of chromosome regions or entire chromosomes, and mutations in the gene-activating promoter of TERT, which encodes an enzyme implicated

TL;DR: In this paper, the authors present compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissue, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues.

TL;DR: Recent developments in single-cell expression profiling and studies applying them in clinical settings are described, highlighting some of the powerful insights gleaned from these studies for tumor classification, stem cell programs, tumor microenvironment, metastasis, and response to targeted and immune therapies.

TL;DR: The findings extend discoveries of chromatin regulator inactivation and gain-of-function mutations by documenting alteration of a modifiable histone residue in human cancer.