M
Mario L. Suvà
Researcher at Harvard University
Publications - 107
Citations - 18610
Mario L. Suvà is an academic researcher from Harvard University. The author has contributed to research in topics: Glioma & Biology. The author has an hindex of 38, co-authored 86 publications receiving 12505 citations. Previous affiliations of Mario L. Suvà include Massachusetts Institute of Technology & Howard Hughes Medical Institute.
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Journal ArticleDOI
The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution
Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,Aviv Regev,Philipp Oberdoerffer,Tal Nawy,Anna Hupalowska,Jennifer Rood,Orr Ashenberg,Ethan Cerami,Robert J. Coffey,Emek Demir,Li Ding,Edward D. Esplin,James M. Ford,Jeremy Goecks,Sharmistha Ghosh,Joe W. Gray,Justin Guinney,Justin Guinney,Sean E. Hanlon,Shannon K. Hughes,E. Shelley Hwang,Christine A. Iacobuzio-Donahue,Judit Jané-Valbuena,Bruce E. Johnson,Ken S. Lau,Tracy Lively,Sarah A. Mazzilli,Dana Pe'er,Sandro Santagata,Sandro Santagata,Alex K. Shalek,Denis Schapiro,Denis Schapiro,Michael Snyder,Peter K. Sorger,Avrum E. Spira,Avrum E. Spira,Sudhir Srivastava,Kai Tan,Kai Tan,Robert West,Elizabeth H. Williams,Elizabeth H. Williams,Denise Aberle,Samuel Achilefu,Foluso O. Ademuyiwa,Andrew Adey,Rebecca Aft,Rachana Agarwal,Ruben A. Aguilar,Fatemeh Alikarami,Viola Allaj,Christopher I. Amos,Robert A. Anders,Michael R. Angelo,Kristen Anton,Jon C. Aster,Özgün Babur,Amir Bahmani,Akshay Balsubramani,David M. Barrett,Jennifer Beane,Diane Bender,Kathrin M. Bernt,Lynne D. Berry,Courtney Betts,Julie Bletz,Katie Blise,Adrienne Boire,Genevieve M. Boland,Alexander D. Borowsky,Kristopher R. Bosse,Matthew J. Bott,Edward S. Boyden,James D. Brooks,Raphael Bueno,Erik A. Burlingame,Qiuyin Cai,Joshua D. Campbell,Wagma Caravan,Hassan Chaib,Joseph M. Chan,Young Hwan Chang,Deyali Chatterjee,Ojasvi Chaudhary,Alyce A. Chen,Bob Chen,Changya Chen,Chia hui Chen,Feng Chen,Yuan Chen,Milan G. Chheda,Koei Chin,Roxanne Chiu,Shih Kai Chu,Rodrigo Chuaqui,Jaeyoung Chun,Luis Cisneros,Graham A. Colditz,Kristina A. Cole,Natalie B. Collins,Kévin Contrepois,Lisa M. Coussens,Allison L. Creason,Daniel J. Crichton,Christina Curtis,Tanja M. Davidsen,Sherri R. Davies,Ino de Bruijn,Laura DelloStritto,Angelo M. De Marzo,David G. DeNardo,Dinh Diep,Sharon J. Diskin,Xengie Doan,Julia L. Drewes,Stephen Dubinett,Michael A. Dyer,Jacklynn V. Egger,Jennifer Eng,Barbara E. Engelhardt,Graham Erwin,Laura J. Esserman,Alex Felmeister,Heidi S. Feiler,Ryan C. Fields,Stephen A. Fisher,Keith T. Flaherty,Jennifer Flournoy,Angelo Fortunato,Allison Frangieh,Jennifer L. Frye,Robert S. Fulton,Danielle Galipeau,Siting Gan,Jianjiong Gao,Long Gao,Peng Gao,Vianne R. Gao,Tim Geiger,Ajit George,Gad Getz,Marios Giannakis,David L Gibbs,William E. Gillanders,Simon P. Goedegebuure,Alanna Gould,Kate H.C. Gowers,William J. Greenleaf,Jeremy Gresham,Jennifer L. Guerriero,Tuhin Kumar Guha,Alexander R. Guimaraes,David A. Gutman,Nir Hacohen,Sean E. Hanlon,Casey R. Hansen,Olivier Harismendy,Kathleen A. Harris,Aaron N. Hata,Akimasa Hayashi,Cody N. Heiser,Karla Helvie,John M. Herndon,Gilliam Hirst,Frank Hodi,Travis J. Hollmann,Aaron M. Horning,James J. Hsieh,Shannon Hughes,Won Jae Huh,Stephen P. Hunger,Shelley Hwang,Heba Ijaz,Benjamin Izar,Connor A. Jacobson,Sam M. Janes,Reyka G Jayasinghe,Lihua Jiang,Brett Johnson,Bruce E. Johnson,Tao Ju,Humam Kadara,Klaus H. Kaestner,Jacob Kagan,Lukas Kalinke,Robert L. Keith,Aziz Khan,Warren A. Kibbe,Albert H. Kim,Erika Kim,Junhyong Kim,Annette Kolodzie,Mateusz Kopytra,Eran Kotler,Robert Krueger,Kostyantyn Krysan,Anshul Kundaje,Uri Ladabaum,Blue B. Lake,Huy Lam,Rozelle Laquindanum,Ashley M. Laughney,Hayan Lee,Marc E. Lenburg,Carina A. Leonard,Ignaty Leshchiner,Rochelle Levy,Jerry Li,Christine G. Lian,Kian-Huat Lim,Jia-Ren Lin,Yiyun Lin,Qi Liu,Ruiyang Liu,William J.R. Longabaugh,Teri A. Longacre,Cynthia X. Ma,Mary Catherine Macedonia,Tyler Madison,Christopher G. Maher,Anirban Maitra,Netta Makinen,Danika Makowski,Carlo C. Maley,Zoltan Maliga,Diego Mallo,John M. Maris,Nick Markham,Jeffrey R. Marks,Daniel Martinez,Robert J. Mashl,Ignas Masilionais,Jennifer Mason,Joan Massagué,Pierre P. Massion,Marissa Mattar,Richard Mazurchuk,Linas Mazutis,Eliot T. McKinley,Joshua F. McMichael,Daniel T. Merrick,Matthew Meyerson,Julia R. Miessner,Gordon B. Mills,Meredith A. Mills,Suman B. Mondal,Motomi Mori,Yuriko Mori,Elizabeth Moses,Yael P. Mosse,Jeremy L. Muhlich,George F. Murphy,Nicholas Navin,Michel Nederlof,Reid M. Ness,Stephanie A. Nevins,Milen Nikolov,Ajit J. Nirmal,Garry P. Nolan,Edward Novikov,Brendan O'Connell,Michael Offin,Stephen T. Oh,Anastasiya Olson,Alex Ooms,Miguel Ossandon,Kouros Owzar,Swapnil Parmar,Tasleema Patel,Gary J. Patti,Itsik Pe'er,Tao Peng,Daniel Persson,Marvin Petty,Hanspeter Pfister,Kornelia Polyak,Kamyar Esmaeili Pourfarhangi,Sidharth V. Puram,Qi Qiu,Álvaro Quintanal-Villalonga,Arjun Raj,Marisol A. Ramirez-Solano,Rumana Rashid,Ashley N. Reeb,Mary E. Reid,Adam C. Resnick,Sheila Reynolds,Jessica L. Riesterer,Scott J. Rodig,Joseph T. Roland,Sonia Rosenfield,Asaf Rotem,Sudipta Roy,Charles M. Rudin,Marc D. Ryser,Maria Santi-Vicini,Kazuhito Sato,Deborah Schrag,Nikolaus Schultz,Cynthia L. Sears,Rosalie C. Sears,Subrata Sen,Triparna Sen,Alex K. Shalek,Jeff Sheng,Quanhu Sheng,Kooresh I. Shoghi,Martha J. Shrubsole,Yu Shyr,Alexander B. Sibley,Kiara Siex,Alan J. Simmons,Dinah S. Singer,Shamilene Sivagnanam,Michal Slyper,Artem Sokolov,Sheng-Kwei Song,Austin N. Southard-Smith,Avrum Spira,Janet Stein,Phillip B. Storm,Elizabeth H. Stover,Siri H. Strand,Timothy Su,Damir Sudar,Ryan P. Sullivan,Lea F. Surrey,Mario L. Suvà,Nadezhda V. Terekhanova,Luke Ternes,Lisa Thammavong,Guillaume Thibault,George Thomas,Vesteinn Thorsson,Ellen Todres,Linh M. Tran,Madison Tyler,Yasin Uzun,Anil Vachani,Eliezer M. Van Allen,Simon N. Vandekar,Deborah J. Veis,Sébastien Vigneau,Arastoo Vossough,Angela J. Waanders,Nikhil Wagle,Liang-Bo Wang,Michael C. Wendl,Robert B. West,Chi yun Wu,Hao Wu,Hung Yi Wu,Matthew A. Wyczalkowski,Yubin Xie,Xiaolu Yang,Clarence Yapp,Wenbao Yu,Yinyin Yuan,Dadong Zhang,Kun Zhang,Mianlei Zhang,Nan Zhang,Yantian Zhang,Yanyan Zhao,Daniel Cui Zhou,Zilu Zhou,Houxiang Zhu,Qin Zhu,Xiangzhu Zhu,Yuankun Zhu,Xiaowei Zhuang +373 more
TL;DR: The Human Tumor Atlas Network (HTAN), part of the NCI Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types.
Ews-fli-1 expression triggers a ewing’s sarcoma initiation program in primary human mesenchymal stem cells
Domizio Suva,Nicolo Riggi,Mario L. Suvà,Luisa Cironi,Paolo Provero,Vincent Kindler,Ivan Stamenkovic +6 more
TL;DR: The authors showed that expression of EWS-FLI1 in primary human mesenchymal stem cells (hMSC) is not only stably maintained without inhibiting proliferation, but also induces a gene expression profile bearing striking similarity to that of Ewing's sarcoma family tumors, including genes that are among the highest ESFT discriminators.
Journal ArticleDOI
Single-Cell RNA Sequencing in Cancer: Lessons Learned and Emerging Challenges.
TL;DR: Some of the common themes emerging from initial studies of single-cell RNA sequencing in cancer are discussed and challenges in cancer biology are highlighted for which emerging single- cell genomics methods may provide a compelling approach.
Journal ArticleDOI
An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma
Esther Rheinbay,Mario L. Suvà,Mario L. Suvà,Mario L. Suvà,Shawn M. Gillespie,Shawn M. Gillespie,Shawn M. Gillespie,Hiroaki Wakimoto,Anoop P. Patel,Mohammad Shahid,Ozgur Oksuz,Samuel D. Rabkin,Robert L. Martuza,Miguel Rivera,Miguel Rivera,David N. Louis,Simon Kasif,Andrew S. Chi,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +20 more
TL;DR: A comparative analysis of chromatin state in GBM CSCs is presented that reveals widespread activation of genes normally held in check by Polycomb repressors, and demonstrates regulatory connections among ASCL1, Wnt signaling, and collaborating TFs that are essential for the maintenance and tumorigenicity of GBMCSCs.
Journal ArticleDOI
Resolving medulloblastoma cellular architecture by single-cell genomics
Volker Hovestadt,Volker Hovestadt,Kyle S. Smith,Laure Bihannic,Mariella G. Filbin,Mariella G. Filbin,Mariella G. Filbin,McKenzie Shaw,McKenzie Shaw,McKenzie Shaw,Alicia Baumgartner,Alicia Baumgartner,John C. DeWitt,John C. DeWitt,Andrew P Groves,Lisa Mayr,Hannah R. Weisman,Hannah R. Weisman,Alyssa R. Richman,Alyssa R. Richman,Marni E. Shore,Marni E. Shore,Liliana Goumnerova,Celeste Rosencrance,Robert A. Carter,Timothy N. Phoenix,Jennifer Hadley,Yiai Tong,Jim Houston,Richard A. Ashmun,Michael DeCuypere,Tanvi Sharma,Diane Flasch,Antonina Silkov,Keith L. Ligon,Keith L. Ligon,Scott L. Pomeroy,Miguel Rivera,Miguel Rivera,Orit Rozenblatt-Rosen,Orit Rozenblatt-Rosen,Jessica M. Rusert,Robert J. Wechsler-Reya,Xiao-Nan Li,Andreas Peyrl,Johannes Gojo,Dominik Kirchhofer,Daniela Lötsch,Thomas Czech,Christian Dorfer,Christine Haberler,René Geyeregger,René Geyeregger,Angela Halfmann,Charles Gawad,John Easton,Stefan M. Pfister,Stefan M. Pfister,Aviv Regev,Aviv Regev,Amar Gajjar,Brent A. Orr,Irene Slavc,Giles W. Robinson,Bradley E. Bernstein,Bradley E. Bernstein,Mario L. Suvà,Mario L. Suvà,Paul A. Northcott +68 more
TL;DR: Characterization of medulloblastoma tissues using single-cell transcriptomics shows that the different molecular subtypes consist of distinct developmental phenotypes, which provides insights into the cellular and developmental states underlying subtype-specific medullOBlastoma biology.