M
Mario L. Suvà
Researcher at Harvard University
Publications - 107
Citations - 18610
Mario L. Suvà is an academic researcher from Harvard University. The author has contributed to research in topics: Glioma & Biology. The author has an hindex of 38, co-authored 86 publications receiving 12505 citations. Previous affiliations of Mario L. Suvà include Massachusetts Institute of Technology & Howard Hughes Medical Institute.
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Journal ArticleDOI
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma
Xiuxing Wang,Kailin Yang,Kailin Yang,Qi Xie,Qiulian Wu,Stephen C. Mack,Yu Shi,Yu Shi,Leo J.Y. Kim,Briana C. Prager,Briana C. Prager,William A. Flavahan,Xiaojing Liu,Meromit Singer,Christopher G. Hubert,Tyler E. Miller,Wenchao Zhou,Zhi Huang,Xiaoguang Fang,Aviv Regev,Mario L. Suvà,Mario L. Suvà,Tae Hyun Hwang,Jason W. Locasale,Shideng Bao,Jeremy N. Rich,Jeremy N. Rich +26 more
TL;DR: Wang et al. as mentioned in this paper reported that de novo purine biosynthesis reprograms BTIC metabolism, revealing a potential point of fragility amenable to targeted cancer therapy.
Journal ArticleDOI
Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing.
Qin Tang,Sowmya Iyer,Riadh Lobbardi,John C. Moore,Huidong Chen,Huidong Chen,Caleb A. Lareau,Christine Hebert,Christine Hebert,McKenzie Shaw,McKenzie Shaw,Cyril Neftel,Cyril Neftel,Mario L. Suvà,Mario L. Suvà,Craig J. Ceol,Andre Bernards,Martin J. Aryee,Luca Pinello,Iain A. Drummond,David M. Langenau +20 more
TL;DR: This work provides the first, comprehensive, single-cell, transcriptomic analysis of kidney and marrow cells in the adult zebrafish, uncovering novel cell types including two classes of natural killer immune cells, classically defined and erythroid-primed hematopoietic stem and progenitor cells, mucin-secreting kidney cells, and kidney stem/progenitor cells.
Journal ArticleDOI
Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis.
Qinjie Weng,Qinjie Weng,Jincheng Wang,Jincheng Wang,Jiajia Wang,Jiajia Wang,Danyang He,Zuolin Cheng,Feng Zhang,Feng Zhang,Ravinder Verma,Lingli Xu,Lingli Xu,Xinran Dong,Yunfei Liao,Xuelian He,Andrew S. Potter,Liguo Zhang,Chuntao Zhao,Mei Xin,Qian Zhou,Bruce J. Aronow,Perry J. Blackshear,Jeremy N. Rich,Qiaojun He,Wenhao Zhou,Mario L. Suvà,Ronald R. Waclaw,S. Steven Potter,Guoqiang Yu,Q. Richard Lu,Q. Richard Lu +31 more
TL;DR: The results resolve the dynamic repertoire of common and divergent glial progenitors during development and tumorigenesis and highlight Zfp36l1 as a molecular nexus for balancing glial cell-fate decision and controlling gliomagenesis.
Journal ArticleDOI
The Glioma Stem Cell Model in the Era of Single-Cell Genomics.
TL;DR: It is highlighted how classes of glioma differ in their cellular architecture and relate the observed cellular states to established GSC markers, and a set of single-cell informed definitions are proposed as a framework for understanding of the cellular architecture ofgliomas and a potential therapeutic outlook.
Journal ArticleDOI
Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG
Jamie N. Anastas,Barry M. Zee,Barry M. Zee,Jay H. Kalin,Mirhee Kim,Robyn Guo,Sanda Alexandrescu,Mario Andres Blanco,Stefanie Giera,Shawn M. Gillespie,Jayanta Das,Muzhou Wu,Sarah E. Nocco,Dennis M. Bonal,Quang-Dé Nguyen,Mario L. Suvà,Bradley E. Bernstein,Bradley E. Bernstein,Rhoda M. Alani,Todd R. Golub,Philip A. Cole,Philip A. Cole,Mariella G. Filbin,Mariella G. Filbin,Yang Shi,Yang Shi +25 more
TL;DR: A CRISPR screen revealing that knockout of KDM1A encoding lysine-specific demethylase 1 (LSD1) sensitizes DIPG cells to histone deacetylase (HDAC) inhibitors is conducted, suggesting a strategy for treating DIPGs by simultaneously inhibiting LSD1 and HDACs.