Marios Georgiadis

TL;DR: The main mechanical effect of AGEs is a loss of tissue viscoelasticity driven by matrix-level loss of fiber-fiber sliding, which has potentially important implications to tissue damage accumulation, mechanically regulated cell signaling, and matrix remodeling.

TL;DR: An imaging method is introduced that combines small-angle scattering with tensor tomography to probe nanoscale structures in three-dimensional macroscopic samples in a non-destructive way and allows, for example, the role of ultrastructure in the mechanical response of a biological tissue or manufactured material to be studied.

TL;DR: A broad range of imaging techniques and the different modalities of their use are discussed in order to discuss their advantages and limitations for the assessment of bone ultrastructure organization with respect to the orientation and arrangement of mineralized collagen fibrils.

TL;DR: μIHC using a microfluidic probe is preservative of tissue samples and reagents, alleviates antibody cross-reactivity issues, and allows a wide range of staining conditions to be applied on a single tissue section, and may find broad use in tissue-based diagnostics and in research.

TL;DR: 3D orientation maps such as the ones created using 3D scanning SAXS will help to quantify and understand structure-function relationships between bone ultrastructure and bone mechanics and can also be used in other research fields such as material sciences.