M
Marius Surleac
Researcher at University of Bucharest
Publications - 21
Citations - 327
Marius Surleac is an academic researcher from University of Bucharest. The author has contributed to research in topics: V(D)J recombination & Acinetobacter baumannii. The author has an hindex of 8, co-authored 18 publications receiving 192 citations. Previous affiliations of Marius Surleac include Yale University & Romanian Academy.
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Journal ArticleDOI
Transposon molecular domestication and the evolution of the RAG recombinase
Yuhang Zhang,Tat Cheung Cheng,Guangrui Huang,Qingyi Lu,Marius Surleac,Jeffrey D. Mandell,Pierre Pontarotti,Pierre Pontarotti,Andrei J. Petrescu,Anlong Xu,Anlong Xu,Yong Xiong,David G. Schatz +12 more
TL;DR: A two-tiered mechanism for the suppression of RAG-mediated transposition is revealed, the evolution of V(D)J recombination is illuminated, and insight is provided into the principles that govern the molecular domestication of transposons.
Journal ArticleDOI
Whole genome sequencing snapshot of multi-drug resistant Klebsiella pneumoniae strains from hospitals and receiving wastewater treatment plants in Southern Romania.
Marius Surleac,Ilda Czobor Barbu,Simona Paraschiv,Laura Ioana Popa,Irina Gheorghe,Irina Gheorghe,Luminita Marutescu,Luminita Marutescu,Marcela Popa,Ionela Sarbu,Daniela Tălăpan,Mihai Nita,Alina Viorica Iancu,Manuela Arbune,Alina Manole,Serban Nicolescu,Oana Săndulescu,Adrian Streinu-Cercel,Dan Otelea,Mariana Carmen Chifiriuc +19 more
TL;DR: The genomic characterization of 47 multi-drug resistant, carbapenem resistant and ESBL-producing K. pneumoniae isolates from the influent versus effluent wastewater samples could be used as markers for the efficiency of the WWTPs in eliminating AR bacteria and ARGs.
Journal ArticleDOI
RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes
Mihai Ciubotaru,Adam J. Trexler,Laurentiu N. Spiridon,Marius Surleac,Elizabeth Rhoades,Andrei J. Petrescu,David G. Schatz +6 more
TL;DR: A model in which the 23RSS adopts a U shape in the PC is proposed, which facilitates simultaneous recognition of the heptamer and nonamer, is critical for proper positioning of the active site and contributes to the 12/23 rule.
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Multidrug Resistant Klebsiella pneumoniae ST101 Clone Survival Chain From Inpatients to Hospital Effluent After Chlorine Treatment
Laura Ioana Popa,Irina Gheorghe,Ilda Czobor Barbu,Marius Surleac,Simona Paraschiv,Luminiţa Măruţescu,Marcela Popa,Graţiela Grădişteanu Pîrcălăbioru,Daniela Tălăpan,Mihai Niţă,Anca Streinu-Cercel,Adrian Streinu-Cercel,Dan Oţelea,Mariana Carmen Chifiriuc +13 more
TL;DR: In this paper, the authors describe the transmission of a multi-drug resistant Klebsiella pneumoniae ST101 clone from hospital to wastewater and its persistence after chlorine treatment, raising the risk of surface water contamination and further dissemination to different components of the trophic chain.
Journal ArticleDOI
Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint
Toshiyuki Kozuki,Kenichi Chikamori,Marius Surleac,Marius A. Micluta,Andrei J. Petrescu,Eric J. Norris,Paul Elson,Gerald A. Hoeltge,Dale Grabowski,Andrew C.G. Porter,Ram N. Ganapathi,Mahrukh K. Ganapathi +11 more
TL;DR: It is demonstrated that the decatenation checkpoint is regulated, not only by topo IIα, as previously reported, but also bytopo IIβ, and this results suggest that toposomerase II α and IIβ cooperate to maintain genome stability, which may be distinctly modulated by their CTDs.