Marjolein V. Smith

TL;DR: A C. elegans larval growth and development assay for medium- and high-throughput screening using the COPAS Biosort flow cytometer is described and descriptions of the data and subsequent analysis are provided.

TL;DR: Together, these data shed light on the molecular pathways regulated by proneural genes and demonstrate that the integration of experimentation with bioinformatics can guide both hypothesis testing and hypothesis generation.

TL;DR: To determine the effects of potential neurotoxicants on C. elegans, four medium-throughput (feeding, growth, reproduction and locomotion) and two high-Throughput (growth and reproduction) assays have been developed and will prove useful in evaluating the role of alternative toxicological models in tiered toxicity testing of thousands of chemicals.

TL;DR: An assay is presented that quantitatively and reliably describes the effects of chemical toxicants on Caenorhabditis elegans growth and development and found significant overlap in the activity of chemicals in the ToxCast™ libraries between C. elegans and zebrafish developmental screens.

TL;DR: This study supports the utility of the C. elegans growth assay and mathematical modeling in determining the effects of potentially toxic substances in an alternative model organism using high-throughput technologies.