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Mark A. Lawson

Researcher at University of California, San Diego

Publications -  79
Citations -  2313

Mark A. Lawson is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Gonadotropin-releasing hormone & Gonadotropic cell. The author has an hindex of 30, co-authored 77 publications receiving 2164 citations. Previous affiliations of Mark A. Lawson include University of Alabama at Birmingham & University of California, Irvine.

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Journal ArticleDOI

A Neuron-Specific Enhancer Targets Expression of the Gonadotropin-Releasing Hormone Gene to Hypothalamic Neurosecretory Neurons

TL;DR: The GnRH gene is targeted to hypothalamic neurons by a complex multicomponent enhancer that relies on the interaction of multiple nuclear-protein binding enhancer elements.
Journal ArticleDOI

Pulse sensitivity of the luteinizing hormone β promoter is determined by a negative feedback loop involving early growth response-1 and ngfi-A binding protein 1 and 2

TL;DR: Examination of gene expression in LbetaT2 gonadotropes under various pulse regimes in a cell perifusion system by microarray suggests a model of pulse frequency detection that acts by suppressing activation by Egr family members at low frequency and allowing activation at sustained high-frequency pulses.
Journal ArticleDOI

GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene.

TL;DR: It is shown that members of the GATA family of transcription factors regulate GnRH transcription through two GATA factor-binding motifs that occur in a tandem repeat within the GnRH neuron-specific enhancer.
Book ChapterDOI

Picornavirus protein processing--enzymes, substrates, and genetic regulation.

TL;DR: An examination of the nature of Picornavirus proteinases and their polyprotein substrates will be presented in order to underscore the unifying principles of proteolytic cleavage and to point out the peculiar differences in processing strategies among the different picornaviruses.